Safety Data Sheet

SECTION 1. IDENTIFICATION:
Trade name: Okadaic Acid, Free Acid
Product Number: O-2220
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
+1-781-937-0777 Fax: +1-781-938-5420

SECTION 2. HAZARD(S) IDENTIFICATION:
Hazard Description: Toxic; Irritant
Substance Class Identifier: Tumorigen; Mutagen; Natural Product; Human Data
Toxic if swallowed, inhaled, or absorbed through the skin
Ingestion will result in diarrhea, vomiting, abdominal pain and cramping
Irritating to skin and respiratory system; may cause eye irritation
Signal Word: Danger
GHS Hazard Statements:
H301 - Toxic if swallowed
H311 - Toxic in contact with skin
H315 - Causes skin irritation
H331 - Toxic if inhaled
H335 - May cause respiratory irritation
GHS Precautionary Statements:
P261 - Avoid breathing dust/fume/gas/mist/vapours/spray
P280 - Wear protective gloves/eye protection/face protection
P301 + P310 - IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
P330 - Rinse mouth
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P312 - Call a POISON CENTER or doctor/physician if you feel unwell
P332 + P313 - If skin irritation occurs: Get medical advice/attention
P361 - Take off immediately all contaminated clothing
P403 + P233 - Store in a well-ventilated place. Keep container tightly closed
P405 - Store locked up
P501 - Dispose of contents/container to an approved waste disposal plant
ToxicHarmful

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS:
Chemical Name: (αR,2S,5R,6R,8S)-α,5-dihydroxy-α,10-dimethyl-8-[(1R,2E)-1-methyl-3-[(2R,4'aR,5R,6'S,8'R,8'aS)-octahydro-8'-hydroxy-6'-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl]-7'-methylenespiro[furan-2(3H),2'(3'H)-pyrano[3,2-b]pyran]-5-yl]-2-propen-1-yl]-1,7-dioxaspiro[5.5]undec-10-ene-2-propanoic acid
Synonyms: 9,10-deepithio-9,10-didehydro-acanthifolicin, Halochondrine A
Hazardous Ingredient: Okadaic Acid
CAS Registry Number: 78111-17-8
Molecular Weight: 805.00
Molecular Formula: C44H68O13

SECTION 4. FIRST-AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician

SECTION 5. FIRE-FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Unusual fire hazard: may emit toxic fumes under fire conditions

SECTION 6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13

SECTION 7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: crystalline solid or clear, colorless film
Color: white
Odor: none
Melting point/Melting range: not determined
Danger of explosion: none
Solubility in / Miscibility with water: not determined
Solvent content: none
Organic solvents: soluble in DMSO, methanol, or ethanol

SECTION 10. STABILITY AND REACTIVITY:
Stability: avoid acids and bases
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide and carbon dioxide

SECTION 11. TOXICOLOGICAL INFORMATION:
RTECS #: AA8227800
Acute toxicity: intraperitoneal toxicity (LD50): 192 µg/kg (mouse)
On the skin: causes skin irritation; harmful if absorbed through the skin
On the eye: causes eye irritation
Inhalation: causes respiratory tract irritation; harmful if inhaled
Ingestion: harmful if swallowed

SECTION 12. ECOLOGICAL INFORMATION:
General notes: no data available
Treat as potentially toxic if released into the environment

SECTION 13. DISPOSAL CONSIDERATIONS:
Dispose of in accordance with prevailing country, federal, state and local regulations

SECTION 14. TRANSPORT INFORMATION:
UN number: 3462
DOT: Toxins, extracted from living sources, solid, n.o.s. (Okadaic acid), Class: 6.1, Packing group: I
IMDG: Toxins, extracted from living sources, solid, n.o.s. (Okadaic acid), Class: 6.1, Packing group: I
IATA: Toxins, extracted from living sources, solid, n.o.s. (Okadaic acid), Class: 6.1, Packing group: I

SECTION 15. REGULATORY INFORMATION:
Code letter and hazard designation of product:
T: Toxic, Xi: Irritant
EU Risk And Safety phrases:
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S46: If swallowed, seek medical advice immediately and show this container or label
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed
R37/38: Irritating to respiratory system and skin

SECTION 16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability
Revision Date:  May 26, 2016