Safety Data Sheet

SECTION 1. IDENTIFICATION:
Trade name: Phorbol 12-Myristate 13-Acetate
Product Number: P-1680
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
+1-781-937-0777 Fax: +1-781-938-5420

SECTION 2. HAZARD(S) IDENTIFICATION:
Hazard Description: Caution! Tumor promoter
Substance Class Identifier: Tumorigen; Mutagen; Human Data; Primary Irritant; Reproductive Effector
Potent irritant; causes irritation to eyes, skin, mucous membranes
May be harmful if swallowed, inhaled, or absorbed through the skin
Laboratory experiments on animals have reported the development of tumors
Mutagenic for mammalian somatic cells and for bacteria and/or yeast
Signal Word: Warning
GHS Hazard Statements:
H303 - May be harmful if swallowed
H313 - May be harmful in contact with skin
H315 - Causes skin irritation
H320 - Causes eye irritation
H333 - May be harmful if inhaled
H335 - May cause respiratory irritation
GHS Precautionary Statements:
P260 - Do not breathe dust/fume/gas/mist/vapours/spray
P264 - Wash skin thoroughly after handling
P280 - Wear protective gloves/eye protection/face protection
P301 + P312 - IF SWALLOWED: Call a POISON CENTER or doctor/physician
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
P308 + P311 - IF exposed or concerned: Call a POISON CENTER or doctor/physician
P333 + P313 - If skin irritation or a rash occurs: Get medical advice/attention
P337 + P313 - If eye irritation persists: Get medical advice/attention
P362 + 364 - Take off contaminated clothing and wash it before reuse
P501 - Dispose of contents/container in accordance with local/regional/national/international regulations

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS:
Chemical Name: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(Acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9-yl tetradecanoate
Synonyms: PMA, 12-O-Tetradecanoylphorbol-13-acetate, TPA
Hazardous Ingredient: Phorbol 12-Myristate 13-Acetate
CAS Registry Number: 16561-29-8
Molecular Weight: 616.83
Molecular Formula: C36H56O8

SECTION 4. FIRST-AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician; under care of a physician, prompt application of steroidal antiinflammatory creams may reduce or prevent skin irritation
After eye contact: flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician; under care of a physician, application of steroidal antiinflammatory creams may reduce or prevent eye irritation
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician; under care of a physician, application of steroid antiinflammatory creams may reduce irritation

SECTION 5. FIRE-FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Unusual fire hazard: may emit toxic fumes under fire conditions

SECTION 6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol to remove bulk material followed by treatment of surfaces and equipment with 5% hypochlorite solution; dispose of contaminated material according to Section 13

SECTION 7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: amorphous solid in the form of a film or foam
Color: colorless
Odor: none
Melting point/Melting range: not determined
Danger of explosion: none
Solubility in / Miscibility with water: not soluble
Solvent content:
Organic solvents: soluble in DMSO and ethanol

SECTION 10. STABILITY AND REACTIVITY:
Stability: avoid acids and bases
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide and carbon dioxide

SECTION 11. TOXICOLOGICAL INFORMATION:
RTECS #: QH4377000
Acute toxicity: intraperitoneal toxicity (LD): >1 mg/kg (mouse); intravenous toxicity (LD50): 309 µg/kg (mouse)
Primary irritant effect:
On the skin: causes skin irritation
On the eye: causes eye irritation
Inhalation: irritating to the respiratory tract; may be harmful if inhaled
Ingestion: may be harmful if swallowed; ay cause irritation of the digestive tract

SECTION 12. ECOLOGICAL INFORMATION:
General notes: no data available
Treat as potentially toxic if released into the environment

SECTION 13. DISPOSAL CONSIDERATIONS:
Dispose of in accordance with prevailing country, federal, state and local regulations

SECTION 14. TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport

SECTION 15. REGULATORY INFORMATION:
Code letter and hazard designation of product:
Xi: Irritant
EU Risk And Safety phrases:
S22: Do not breathe dust
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S27: Take off immediately all contaminated clothing
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
R21: Harmful in contact with skin
R36/37/38: Irritating to eyes, respiratory system and skin

SECTION 16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability
Revision Date:  February 1, 2015