Safety Data Sheet

SECTION 1. IDENTIFICATION:
Trade name: Staurosporine
Product Number: S-9300
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
+1-781-937-0777 Fax: +1-781-938-5420

SECTION 2. HAZARD(S) IDENTIFICATION:
Hazard Description: Toxic
Substance Class Identifier: Mutagen; Human Data
Toxic if swallowed or inhaled; may be harmful if absorbed through the skin
Suspected of causing genetic defects and cancer
Exposure may cause irritation to eyes, mucous membranes, upper respiratory tract, and skin
Signal Word: Danger
GHS Hazard Statements:
H301 - Toxic if swallowed
H313 - May be harmful in contact with skin
H331 - Toxic if inhaled
H335 - May cause respiratory irritation
H340 - May cause genetic defects
H350 - May cause cancer
GHS Precautionary Statements:
P201 - Obtain special instructions before use
P202 - Do not handle until all safety precautions have been read and understood
P261 - Avoid breathing dust/fume/gas/mist/vapours/spray
P264 - Wash skin thoroughly after handling
P280 - Wear protective gloves/eye protection/face protection
P301 + P310 - IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
P330 - Rinse mouth
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P310 - Immediately call a POISON CENTER or doctor/physician
P501 - Dispose of contents/container in accordance with local/regional/national/international regulations

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS:
Chemical Name: (9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
Synonyms: AM-2282, Antibiotic 230, Antibiotic AM 2282, CGP 39360, Staurosporin
Hazardous Ingredient: Staurosporine
CAS Registry Number: 62996-74-1
Molecular Weight: 466.53
Molecular Formula: C28H26N4O3

SECTION 4. FIRST-AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician

SECTION 5. FIRE-FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Unusual fire hazard: may emit toxic fumes under fire conditions

SECTION 6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13

SECTION 7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: crystalline solid; granular or powder
Color: white to off-white
Odor: none
Melting point/Melting range: 240-243ºC
Danger of explosion: none
Solubility in / Miscibility with water: very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility
Solvent content: none
Organic solvents: soluble in DMSO at 100 mg/mL; soluble in ethanol at 2.5 mg/mL with warming

SECTION 10. STABILITY AND REACTIVITY:
Stability: avoid acids and bases
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide and carbon dioxide

SECTION 11. TOXICOLOGICAL INFORMATION:
RTECS #: KC6550000
Acute toxicity: subcutaneous toxicity (TDLo): 5.2 µg/kg (rat); in vitro toxicity (IC50): 0.05-1.5 µmol/L (dog kidney); in vitro toxicity (ICLo): O.025 - 20 µmol/L (dog kidney)
Primary irritant effect:
On the skin: may be an irritant; may be harmful if absorbed through the skin
On the eye: may be an irritant
Inhalation: toxic if inhaled; may cause respiratory tract irritation
Ingestion: toxic if swallowed

SECTION 12. ECOLOGICAL INFORMATION:
General notes: no data available
Treat as potentially toxic if released into the environment

SECTION 13. DISPOSAL CONSIDERATIONS:
Dispose of in accordance with prevailing country, federal, state and local regulations

SECTION 14. TRANSPORT INFORMATION:
UN number: 3462
DOT: Toxins, extracted from living sources, solid, n.o.s. (Staurosporine), Class: 6.1, Packing group: II
IMDG: Toxins, extracted from living sources, solid, n.o.s. (Staurosporine), Class: 6.1, Packing group: II
IATA: Toxins, extracted from living sources, solid, n.o.s. (Staurosporine), Class: 6.1, Packing group: II

SECTION 15. REGULATORY INFORMATION:
Code letter and hazard designation of product:
T: Toxic
EU Risk And Safety phrases:
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S28: After contact with skin, wash immediately with plenty of water
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
R23/25: Toxic by inhalation and if swallowed
R45/46: May cause cancer and heritable genetic damage

SECTION 16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability
Revision Date:  February 1, 2015