Safety Data Sheet

SECTION 1. IDENTIFICATION:
Trade name: CHIR99021, Free Base
Product Number: C-6556
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
1-781-937-0777 Fax: 1-781-938-5420

SECTION 2. HAZARD(S) IDENTIFICATION:
Hazard Description: pharmaceutically active substance that has not been fully tested
Harmful if swallowed
May be harmful if inhaled or absorbed through the skin
Irritating to the skin and eyes
May impair fertility or harm the unborn child
Exposure may cause irritation of the respiratory tract and allergic respiratory and skin reaction
Signal Word: Danger
GHS Hazard Statements:
H302 - Harmful if swallowed
H313 - May be harmful in contact with skin
H315 - Causes skin irritation
H319 - Causes serious eye irritation
H333 - May be harmful if inhaled
H335 - May cause respiratory irritation
H361 - Suspected of damaging fertility or the unborn child
GHS Precautionary Statements:
P261 - Avoid breathing dust/fume/gas/mist/vapours/spray
P263 - Avoid contact during pregnancy/while nursing
P264 - Wash skin thoroughly after handling
P280 - Wear protective gloves/eye protection/face protection
P301 + P312 - IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
P312 - Call a POISON CENTER or doctor/physician if you feel unwell
P332 + P313 - If skin irritation occurs: Get medical advice/attention
P337 + P313 - If eye irritation persists: Get medical advice/attention

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS:
Chemical Name: 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H>/i>-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Synonyms: CHIR 911, CT99021, GSK-3 Inhibitor XVI
Hazardous Ingredient: CHIR99021, Free Base
CAS Registry Number: 252917-06-9
Molecular Weight: 465.34
Molecular Formula: C22H18Cl2N8

SECTION 4. FIRST-AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses; flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician

SECTION 5. FIRE-FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Unusual fire hazard: may emit toxic fumes under fire conditions such as carbon monoxide, etc.

SECTION 6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13

SECTION 7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: crystalline solid; granular or powder
Color: off-white
Odor: none
Melting point/Melting range: 125-148 ºC
Danger of explosion: none
Solubility in / Miscibility with water: very poorly soluble in water; maximum solubility in plain water is estimated to be about 20-40 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility
Solvent content:
Organic solvents: soluble in DMSO at 25 mg/mL with warming; very poorly soluble in ethanol

SECTION 10. STABILITY AND REACTIVITY:
Stability: avoid acids and bases
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide and carbon dioxide, and nitrogen oxides

SECTION 11. TOXICOLOGICAL INFORMATION:
RTECS #: not available
Acute toxicity: not known; substance not fully tested
Primary irritant effect:
On the skin: causes skin irritation; may be harmful if absorbed through the skin
On the eye: causes serious eye irritation
Inhalation: may cause irritation of mucous membranes and upper respiratory tract; may be harmful if inhaled
Ingestion: harmful if swallowed

SECTION 12. ECOLOGICAL INFORMATION:
General notes: no data available
Treat as potentially toxic if released into the environment

SECTION 13. DISPOSAL CONSIDERATIONS:
Dispose of in accordance with prevailing country, federal, state and local regulations

SECTION 14. TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport

SECTION 15. REGULATORY INFORMATION:
Code letter and hazard designation of product:
Hazard-determining components of labeling:
EU Risk And Safety phrases:
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S28: After contact with skin, wash immediately with plenty of soap-suds
S36/37/39: Wear protective clothing, gloves and eye/face protection
R22: Harmful if swallowed
R38: Irritating to skin
R41: Risk of serious damage to eyes
R62: Possible risk of impaired fertility
R63: Possible risk of harm to the unborn child

SECTION 16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability
Revision Date:  February 1, 2015