G-7700 Gö 6983, Free Base, >99%

Synonyms : [Go 6983] [Goe 6983]

  • Size
  • US $
  • £
  • ¥
  • 1 mg
  • 34
  • 31
  • 27
  • 3,800
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  • In stock
  • 5 mg
  • 78
  • 71
  • 62
  • 8,600
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  • In stock
  • 10 mg
  • 126
  • 116
  • 100
  • 13,900
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  • 25 mg
  • 247
  • 227
  • 196
  • 27,300
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  • 50 mg
  • 415
  • 382
  • 329
  • 45,900
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  • In stock
  • 100 mg
  • 690
  • 635
  • 548
  • 76,400
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  • In stock

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  • M.W. 442.51
  • C26H26N4O3
  • [133053-19-7]

  • Gö 6983 is a potent, cell-permeable, ATP-competitive inhibitor of protein kinase C (PKC). It inhibited PKC isozymes with IC50 values of 7 nM for PKC[alpha] and PKC[beta]; 6 nM for PKC[gamma]; 10 nM for PKC[delta]; and 60 nM for PKC[zeta]. Gö 6983 weakly inhibited PKC[mu] with an IC50 of 20 µM. Gschwendt M., et al. "Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes." FEBS Lett. 392: 77-80 (1996).
  • PKC inhibitors RO 31-8220 and Gö 6983 increased Akt phosphorylation and enhanced epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets. Kim S.Y., et al. "PKC inhibitors RO 31-8220 and Gö 6983 enhance epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets by enhancing Akt phosphorylation." BMB Rep. 44: 140-145 (2011).
  • The aggregated form of Hsp27 in cultured cells became dissociated as a result of phosphorylation with various types of stress. Phorbol ester (PMA)-induced dissociation of Hsp27 was completely suppressed by staurosporine, Go 6983 and bisindolylmaleimide I, inhibitors of protein kinase C and partially suppressed by SB 203580 or PD 169316, inhibitors of p38 MAP kinase but not by PD 98059 and Uo 126, inhibitors of MAP kinase kinase (MEK). Kato K., et al. "Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27." Cell Stress Chaperones 6: 16-20 (2001).
  • Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use
  • This product is offered for R&D use in accordance with (i) 35 USC 271(e)+A13(1) in the U.S.; (ii) Section 69.1 of Japanese Patent Law in Japan; (iii) Section 11, No. 2 of the German Patent Act of 1981 in Germany; (iv) Section 60, Paragraph 5b of the U.K. Patents Act of 1977 in the U.K.; (v) Sections 55.2(1) and 55.2(6) and other common law exemptions of Canadian patent law; (vi) Section 68B of the Patents Act of 1953 in New Zealand together with the amendment of same by the Statutes Amendment Bill of 2002; (vii) such related legislation and/or case law as may be or become applicable in the aforementioned countries; and (viii) such similar laws and rules as may apply in various other countries.
  • Not available in some countries; not available to some institutions; not available for some uses.
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