Safety Data Sheet

SECTION 1. IDENTIFICATION:
Trade name: Doxorubicin, Hydrochloride Salt
Product Number: D-4000
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
1-781-937-0777 Fax: 1-781-938-5420

SECTION 2. HAZARD(S) IDENTIFICATION:
Hazard Description: Toxic
RTECS Substance category: Tumorigen; Drug; Mutagen; Natural Product; Human Data; Reproductive Effector
May be harmful or fatal if inhaled, swallowed, or absorbed through skin
Exposure may result in damage to the heart, skin, eyes, respiratory system, digestive system, endocrine system, and urinary system
Ingestion may cause complete alopecia (hair loss), onycholysis (separation of nail from nail bed), nail bed hyperpigmentation, rash, itching, urticaria (hives), photosensitivity, acute nausea, vomiting, mucositis (inflammation and ulceration of the mucous membranes lining the digestive tract), anorexia, abdominal pain, dehydration, diarrhea, fever, chills, seizure and coma
Exposure may cause tumors and adversely affect fertility and newborn and breastfed infants
Signal Word: Danger
GHS Hazard Statements:
H302 - Harmful if swallowed
H315 - Causes skin irritation
H319 - Causes serious eye irritation
H335 - May cause respiratory irritation
H350 - May cause cancer
H360 - May damage fertility or the unborn child
H362 - May cause harm to breast-fed children H372 - Causes damage to organs through prolonged or repeated exposure: heart, skin, eyes, respiratory system, digestive system, endocrine system, and urinary system
GHS Precautionary Statements:
P201 - Obtain special instructions before use
P202 - Do not handle until all safety precautions have been read and understood
P260 - Do not breathe dust/fume/gas/mist/vapours/spray
P264 - Wash any exposed skin thoroughly after handling
P270 - Do not eat, drink or smoke when using this product
P280 - Wear protective gloves/eye protection/face protection
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physicianif you feel unwell.
P330 - Rinse mouth
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
P308 + P311 - IF exposed or concerned: Call a POISON CENTER or doctor/physician
P362 + P364 - Take off contaminated clothing and wash it before reuse
P405 - Store locked up
P501 - Dispose of contents/container in accordance with local/regional/national/international regulations

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS:
Chemical Name: (7S,9S)-7-(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione Hydrochloride
Synonyms: Adriacin, Adriamycin, Adriblastin, Adriblastina, Caelyx, Dox, Doxil, Farmiblastina, FI-106, 14-Hydroxydaunomycin, Lipodox, Myocet, Rubex
Hazardous Ingredient: Doxorubicin, Hydrochloride Salt
CAS Registry Number: 25316-40-9
Molecular Weight: 579.98
Molecular Formula: C27H29NO11•HCl

SECTION 4. FIRST-AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses; flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician

SECTION 5. FIRE-FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Unusual fire hazard: may emit toxic fumes under fire conditions such as carbon monoxide, etc.

SECTION 6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with a 10% solution of aqueous sodium hydroxide; dispose of contaminated material according to Section 13

SECTION 7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: crystalline solid; granular or powder
Color: orange
Odor: none
Melting point/Melting range: not determined
Danger of explosion: none
Solubility in / Miscibility with water: soluble in water at 10 mg/mL with slight warming; buffers, serum, or other additives may increase or decrease the aqueous solubility
Solvent content:
Organic solvents: soluble in DMSO at 100 mg/mL; very poorly soluble in ethanol

SECTION 10. STABILITY AND REACTIVITY:
Stability: avoid acids and bases
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide and carbon dioxide, and nitrogen oxides

SECTION 11. TOXICOLOGICAL INFORMATION:
RTECS #: QI9295900
Acute toxicity: intravenous toxicity (TDLo): 12mg/kg (human); intraperitoneal toxicity (LD50): 16030µg/kg (rat); subcutaneous toxicity (LD50): 21840µg/kg (rat); intravenous toxicity (LD50): 12510µg/kg (rat); intramuscular toxicity (LD50): 16mg/kg (rat); oral toxicity (LD50): 698mg/kg (mouse); intraperitoneal toxicity (LD50): 11160µg/kg (mouse); subcutaneous toxicity (LD50): 7678µg/kg (mouse); intramuscular toxicity (LD50): 13700µg/kg (mouse); intravenous toxicity (LD50): 5980µg/kg (rabbit)
Primary irritant effect:
On the skin: irritant; harmful if absorbed through the skin
On the eye: irritant; harmful in contact with eyes
Inhalation: irritant; harmful if inhaled
Ingestion: harmful if swallowed

SECTION 12. ECOLOGICAL INFORMATION:
General notes: no data available

SECTION 13. DISPOSAL CONSIDERATIONS:
Dispose of in accordance with prevailing country, federal, state and local regulations

SECTION 14. TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport

SECTION 15. REGULATORY INFORMATION:
Code letter and hazard designation of product:
T: Toxic
EU Risk And Safety phrases:
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S28: After contact with skin, wash immediately with plenty of water
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
S53: Avoid exposure - obtain special instructions before use
R22: Harmful if swallowed
R37/38: Irritating to respiratory system and skin
R41: Risk of serious damage to eyes
R45: May cause cancer
R46: May cause heritable genetic damage
R62: Possible risk of impaired fertility
R63: Possible risk of harm to the unborn child
R68: Possible risk of irreversible effects

SECTION 16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability
Revision Date:  February 1, 2015