Safety Data Sheet

SECTION 1. IDENTIFICATION:
Trade name: Leptomycin B
Product Number: L-6100
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
+1-781-937-0777 Fax: +1-781-938-5420

SECTION 2. HAZARD(S) IDENTIFICATION:
Hazard Description: Harmful
Substance Class Identifier (refers to Leptomycin B): Drug; Mutagen Substance Class Identifier (refers to Ethanol): Tumorigen; Drug; Mutagen; Natural Product; Human Data; Primary Irritant; Reproductive Effector
May be harmful if swallowed, inhaled, or absorbed through the skin
Exposure may also cause the following: damage to fertility and/or newborn and breastfed infants; general anesthesia, coma, hallucinations/distorted perceptions, arrhythmia, nausea, and vomiting
Exposure may cause irritation to eyes, mucous membranes upper respiratory tract and skin
Signal Word: Danger
H302+312+332 - Harmful if swallowed, in contact with skin or if inhaled
GHS Precautionary Statements:
P2562 - Do not get in eyes, on skin or on clothing
WARNING: For Laboratory Research Use Only

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS:
Chemical Name: (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
Synonyms: LMB, Elactocin, CI-940, CL-1957A, Mantuamycin, NSC-364372, PD-114720
Hazardous Ingredient: Leptomycin B, Ethanol
CAS Registry Number: 87081-35-4 (Leptomycin B); 64-17-5 (Ethanol)
Molecular Weight: 540.73
Molecular Formula: C₃₃H₄₈O₆

SECTION 4. FIRST-AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician

SECTION 5. FIRE-FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Unusual fire hazard: may emit toxic fumes under fire conditions

SECTION 6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13

SECTION 7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: handle with Nitrile rubber gloves with minimum thickness of 0.11 mm (4.3 mil). This recommendation should not be interpreted as offering an approval for any specific use conditions. Please review this recommendation with a safety officer to evaluate if it is appropriate for the anticipated use.
Eye protection: chemical safety goggles

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: solution in absolute ethanol
Color: clear
Odor:
Melting point/Melting range:
Danger of explosion:
Solubility in / Miscibility with water: not soluble
Solvent content:
Organic solvents: soluble in ethanol and methanol

SECTION 10. STABILITY AND REACTIVITY:
Stability: avoid acids and bases
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide and carbon dioxide

SECTION 11. TOXICOLOGICAL INFORMATION:
RTECS #: RA5390000 (Leptomycin B)
Acute toxicity (Leptomycin B): intravenous toxicity (LD50): 3.1 mg/kg (mouse)
On the skin: may be an irritant; may be harmful if absorbed through the skin
On the eye: may be an irritant
Inhalation: may be harmful if inhaled; may be irritating to mucous membranes and upper respiratory tract
Ingestion: may be harmful if swallowed
RTECS #: KQ6300000 (Ethanol)
Acute toxicity (Ethanol): Oral toxicity (LD50): 3450 mg/kg (mouse), 7000-7060 mg/kg (rat); intraperitoneal toxicity (LD50): 528 mg/kg (mouse), 3600 mg/kg (rat), 963 mg/kg (rabbit), 3414 mg/kg (guinea pig), 5068 mg/kg (hamster); intravenous toxicity (LD50): 1973 mg/kg (mouse), 1440 mg/kg (rat), 2374 mg/kg (rabbit); subcutaneous toxicity (LD50): 8285 mg/kg (mouse); intrarterial toxicity (LD50): 11 mg/kg (rat)
On the skin: may cause skin irritation; may be harmful if absorbed through the skin
On the eye: may cause eye irritation
Inhalation: may be harmful if inhaled; may be irritating to mucous membranes and upper respiratory tract
Ingestion: may be harmful if swallowed

SECTION 12. ECOLOGICAL INFORMATION:
General notes: no data available
Treat as potentially toxic if released into the environment

SECTION 13. DISPOSAL CONSIDERATIONS:
Dispose of in accordance with prevailing country, federal, state and local regulations

SECTION 14. TRANSPORT INFORMATION:
UN number: 1170
DOT: Ethanol Solution, Class: 3, Packing group: II
IMDG: Ethanol Solution, Class: 3, Packing group: II
IATA: Ethanol Solution, Class: 3, Packing group: II

SECTION 15. REGULATORY INFORMATION:
Code letter and hazard designation of product:
EU Risk And Safety phrases:
S7: Keep container tightly closed
S9: Keep container in a well ventilated place
S16: Keep away from sources of ignition - no smoking
S24/25: Avoid contact with skin and eyes
S36/37/39: Wear suitable protective clothing, gloves, and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
R11: Highly flammable
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed

SECTION 16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability for any damage resulting from use of this material.
Reviewed:  July 1, 2019