I-6800 Ionomycin, Calcium Salt, >99%

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  • 5 mg
  • 59
  • 49
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  • 10 mg
  • 105
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  • 25 mg
  • 238
  • 198
  • 175
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  • 100 mg
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  • 612
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  • M.W. 747.07
  • C41H70O9•Ca
  • [56092-82-1]

Warnings: Toxic.

Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A.

Certificate of Analysis

  • Antibiotic that acts as a potent and selective calcium ionophore; more effective than A23187. Ionomycin binds Ca2+ in the 7.0-9.5 pH range with the resulting complex exhibiting intense UV absorption. Liu, C. and Hermann T.E. "Characterization of ionomycin as a calcium ionophore." J. Biol. Chem. 253: 5892-5894 (1978). Kauffman, R.F., et al. "Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria." J. Biol. Chem. 255: 2735-2739 (1980).
  • Ionomycin induces apoptosis in immature B cell lines, for example, in Burkitt lymphoma cells, and in cultured embryonic rat cortical neurons. More mature B cell lines do not undergo apoptosis, but are arrested in the G1 phase of the cell cycle. Takei, N. and Endo, Y. "Ca2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons." Brain Res. 652: 65-70 (1994). Aagaard-Tillery, K.M., et al. "Differential activation of a calcium-dependent endonuclease in human B lymphocytes. Role in ionomycin-induced apoptosis." J. Immunol. 155: 3297-3307 (1995).
  • Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
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