S-9344 Stauprimide, >99%

Related Terms : [N-Benzoyl-7-oxostaurosporine]

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  • 1 mg
  • 85
  • 77
  • 65
  • 9,500
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  • 5 mg
  • 380
  • 348
  • 294
  • 42,300
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  • 10 mg
  • 625
  • 573
  • 485
  • 69,500
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  • 25 mg
  • 1,275
  • 1,169
  • 989
  • 141,900
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  • 100 mg
  • 2,550
  • 2,338
  • 1,978
  • 283,700
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  • M.W. 584.62
  • C35H28N4O5
  • [154589-96-5]

Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 100 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A.

  • Stauprimide increases the efficiency of directed differentiation of mouse and human embryonic stem cells (ESCs). Stauprimide binds to NME2 and inhibits its nuclear localization, thus leading to downregulation of c-Myc. Zhu, S., et al. "A small molecule primes embryonic stem cells for differentiation." Cell Stem Cell 4: 416-426 (2009).
  • Stauprimide interacts with NME2, a c-Myc-activating transcription factor that is highly expressed in ESCs. Stauprimide treatment inhibits the nuclear localization of NME2 and downregulates c-Myc, enhances ESC exit from the pluripotent state and enables differentiation. Zaret, K. "Using Small Molecules to Great Effect in Stem Cell Differentiation." Cell Stem Cell 4: 373-374 (2009).
  • Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
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