Safety Data Sheet

SECTION 1. IDENTIFICATION:
Trade name: Paclitaxel
Product Number: P-9600
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
+1-781-937-0777 Fax: +1-781-938-5420


SECTION 2. HAZARD(S) IDENTIFICATION:
Hazard Description: Harmful; Irritant
Harmful if swallowed, inhaled, or by skin absorption
Ingestion may cause leukopenia/neutropenia (different types of reduced white blood cell counts), thrombocytopenia (reduced blood platelets), anemia, pyrexia (fever), nausea, vomiting, diarrhea, mucositis (inflammation/ulceration of the mucous membranes lining the digestive tract, especially mouth sores), dysgeusia (taste alteration), edema (swelling), myalgia/arthralgia (muscle and joint pain), asymptomatic sinus bradycardia (unusually slow heart beat) and other cardiac disturbances, neurotoxicity/peripheral neurosensory manifestations (numbness/tingling in fingers and toes), elevated liver enzymes (AST/ALT) Causes irritation of the skin and eyes; may cause allergic skin reaction
May cause respiratory irritation
May be harmful to the unborn child and may impair fertility
Signal Word: Danger
GHS Hazard Statements:
H302 - Harmful if swallowed
H312 - Harmful in contact with skin
H315 - Causes skin irritation
H317 - May cause an allergic skin reaction
H318 - Causes serious eye damage
H332 - Harmful if inhaled
H335 - May cause respiratory irritation
H341 - Suspected of causing genetic defects
H360 - May damage fertility or the unborn child
GHS Precautionary Statements:
P261 - Avoid breathing dust/fume/gas/mist/vapours/spray
P264 - Wash skin thoroughly after handling
P280 - Wear protective gloves/eye protection/face protection
P301 + P312 - IF SWALLOWED: Call a POISON CENTER or doctor/physician
P330 - Rinse mouth
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
P333 + P313 - If skin irritation or a rash occurs: Get medical advice/attention
P337 + P313 - If eye irritation persists: Get medical advice/attention
P362 + P364 - Take off contaminated clothing and wash it before reuse
P403 + P233 - Store in a well-ventilated place. Keep container tightly closed
P501 - Dispose of contents/container in accordance with local/regional/national/international regulations


SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS:
Chemical Name: (βRS)-β-(benzoylamino)-β-hydroxy-(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester benzenepropanoic acid
Synonyms: Abraxane, BMS-181339, Capxol, Cyclopax, Cynviloq, Genaxol, Genetaxyl, Genexol, Intaxel, Mitotax, Onxal, Pacliex, Paxene, Taxol
Hazardous Ingredient: Paclitaxel
CAS Registry Number: 33069-62-4
Molecular Weight: 853.91
Molecular Formula: C47H51NO14


SECTION 4. FIRST-AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician


SECTION 5. FIRE-FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Unusual fire hazard: may emit toxic fumes under fire conditions


SECTION 6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol to remove bulk material; dispose of contaminated material according to Section 13


SECTION 7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20º C

 

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles


SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: crystalline solid; granular or powder
Color: white
Odor: none
Melting point or range: 210-220 ºC
Danger of explosion: none
Solubility in / Miscibility with water: very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility
Solvent content: none
Organic solvents: soluble in DMSO at 200 mg/mL; soluble in ethanol at 40 mg/mL


SECTION 10. STABILITY AND REACTIVITY:
Stability: avoid acids and bases
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide and carbon dioxide


SECTION 11. TOXICOLOGICAL INFORMATION:
RTECS #: DA8340700
Acute toxicity: intraperitoneal toxicity (LD50): 128 mg/kg (mouse), 32.53 mg/kg (rat); intravenous toxicity (LD50): 7.53-12 mg/kg (mouse), 85 mg/kg (rat)
Primary irritant effect:
On the skin: causes skin irritation; may cause allergic skin reaction; may be harmful if absorbed through the skin
On the eye: causes serious eye damage
Inhalation: may be an irritant; harmful if inhaled
Ingestion: harmful if swallowed


SECTION 12. ECOLOGICAL INFORMATION:
General notes: no data available
Treat as potentially toxic if released into the environment


SECTION 13. DISPOSAL CONSIDERATIONS:
Dispose of in accordance with prevailing country, federal, state and local regulations

 

SECTION 14. TRANSPORT INFORMATION:
UN number: 2811
DOT: Toxic solid, organic, n.o.s. (Paclitaxel), Class: 6.1, Packing group: III
IMDG: Toxic solid, organic, n.o.s. (Paclitaxel), Class: 6.1, Packing group: III
IATA: Toxic solid, organic, n.o.s. (Paclitaxel), Class: 6.1, Packing group: III


SECTION 15. REGULATORY INFORMATION:
Code letter and hazard designation of product:
Xn: Harmful; Xi: Irritant
S22: Do not breathe dust
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed
R36/38: Irritating to eyes and skin
R46: May cause heritable genetic damage
R48: Danger of serious damage to health by prolonged exposure
R60: May impair fertility
R61: May cause harm to the unborn child


SECTION 16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability for any damage resulting from use of this material
Reviewed:  June 1, 2018