Tuesday 27 September 2022 - 04:11
In Business 42 Years - Since 1980
Recently, we have been and are currently operating with: (1) staff shortages related to CV19 and other factors, (2) vacations, (3) a significant health burden for one senior staff member, and (4) dedication of substantial internal resources to a major public-service project. This situation is expected to continue through Sunday, September 11. During this time, we have been and expect to continue entering, processing and shipping orders normally for in-stock products. However, non-order-related communications and production of backordered products will be subject to some unusual delays. We apologize very much for this situation and appreciate your understanding.
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P-1680 Phorbol 12-Myristate 13-Acetate, >99.5%
Synonyms : [Cocarcinogen A1] [12-O-Tetradecanoyl-phorbol 13-Acetate] [PMA] [TPA]
- Size
- US $
- €
- £
- ¥
- 1 mg
- 48
- 49
- 44
- 6,900
- In stock
- 5 mg
- 143
- 148
- 132
- 20,600
- In stock
- 10 mg
- 255
- 264
- 236
- 36,800
- In stock
- 25 mg
- 530
- 549
- 490
- 76,500
- In stock
Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
- M.W. 616.83
- C36H56O8
- [16561-29-8]
- M.I. 12: 7487
- M.I. 14: 7332
Warnings: Highly irritant to skin and mucous membranes. SPECIAL HAZARD: TUMOR PROMOTER. Gloves and mask should be worn when using this compound. Care must be taken to prevent contact through all routes of exposure.
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO or ethanol. Disposal: A.
- LC Labs has been a primary worldwide supplier of PMA for laboratory research for more than 40 years
- More than 330,000 vials of our PMA have been used by many thousands of labs since 1980
- More than a dozen of the world's best-known biochemical reagent vendors resell our PMA under their own label
- This is the most commonly used phorbol ester. It binds to and activates protein kinase C, causes an extremely wide range of effects in cells and tissues, and is a very potent mouse skin tumor promoter. Blumberg, P.M. "In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1." Crit. Rev. Toxicol. 8: 153-197 (1980) and Blumberg, P.M. "In vitro studies on the mode of action of the phorbol esters, potent tumor promoters, part 2." Crit. Rev. Toxicol. 8: 199-234 (1980).
- Although PMA is quite toxic, it has shown anti-leukemic and anti-neutropenic activity in humans. Han, Z.T. et al. "Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia: preliminary studies on therapeutic efficacy and toxicity." Proc. Natl. Acad. Sci. USA 95: 5357-5361 (1998) and Han, Z.T. et al. "12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced increase in depressed white blood cell counts in patients treated with cytotoxic cancer chemotherapeutic drugs." Proc. Natl. Acad. Sci. USA 95: 5362-5365 (1998).
- Beginning with our lot #F-151, we now guarantee purity of 99.5% or greater for this product as measured by HPLC at 254nm.
- Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
