Safety Data Sheet

SAFETY DATA SHEET - LC LABORATORIES
REVISION DATE: JUNE 1, 2018

SECTION 1. IDENTIFICATION:
Trade name: AICAR, Free Base
Product Number: A-1098
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
1-781-937-0777 Fax: 1-781-938-5420


SECTION 2. HAZARD(S) IDENTIFICATION:
Hazard Description: Irritant
May be harmful if ingested, inhaled, or by skin absorption
Irritating to the eyes, skin, and respiratory system
The toxicological properties of this compound have not been thoroughly investigated
Signal Word: Warning
GHS Hazard Statements:
H303 - May be harmful if swallowed
H313 - May be harmful in contact with skin
H315 - Causes skin irritation
H320 - Causes eye irritation
H333 - May be harmful if inhaled
H335 - May cause respiratory irritation
GHS Precautionary Statements:
P261 - Avoid breathing dust/fume/ gas/mist/vapours/spray
P264 - Wash any exposed skin thoroughly after handling
P280 - Wear protective gloves/eye protection/face protection
P302 + P352 - IF ON SKIN: Wash with plenty of soap and water
P304 + P340 - IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
P332 + P313 - If skin irritation occurs: Get medical advice/attention
P337 + P313 - If eye irritation persists: Get medical advice/attention
P362 + P364 - Take off contaminated clothing and wash it before reuse
P403 + P233 - Store in a well-ventilated place. Keep container tightly closed
P405 - Store locked up
P501 - Dispose of contents/container in accordance with local/regional/national/international regulations

 

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS:
Chemical Name: 5-Amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide
Synonyms: Acadesine, AICA-riboside, AIC-Riboside, 5-Aminoimidazole-4-carboxamide riboside, Arasine, GP 1-110, NSC-105823, Protara, Z-Riboside
Hazardous Ingredient: AICAR, Free Base
CAS Registry Number: 2627-69-2
Molecular Weight: 258.23
Molecular Formula: C9H14N4O5


SECTION 4. FIRST-AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses; flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician


SECTION 5. FIRE-FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Unusual fire hazard: may emit toxic fumes under fire conditions such as carbon monoxide, etc.


SECTION 6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13


SECTION 7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC


SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: handle with Nitrile rubber gloves with minimum thickness of 0.11 mm (4.3 mil). This recommendation should not be interpreted as offering an approval for any specific use conditions. Please review this recommendation with a safety officer to evaluate if it is appropriate for the anticipated use.
Eye protection: chemical safety goggles

 

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: crystalline solid; granular or powder
Color: white to off-white
Odor: none
Melting point/Melting range: 210-220 ºC
Danger of explosion: none
Solubility in / Miscibility with water: soluble in water at 20 mg/mL with warming; buffers, serum, or other additives may increase or decrease the aqueous solubility
Solvent content:
Organic solvents: soluble in DMSO at 40 mg/mL; soluble in ethanol at 2 mg/mL with warming


SECTION 10. STABILITY AND REACTIVITY:
Stability: avoid acids and bases
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide and carbon dioxide, and nitrogen oxides


SECTION 11. TOXICOLOGICAL INFORMATION:
RTECS #: not available
Acute toxicity: not known
Primary irritant effect:
On the skin: causes skin irritation; may be harmful if absorbed through the skin
On the eye: causes eye irritation
Inhalation: causes respiratory tract irritation; may be harmful if inhaled
Ingestion: may be harmful if swallowed


SECTION 12. ECOLOGICAL INFORMATION:
General notes: no data available
Treat as potentially toxic if released into the environment


SECTION 13. DISPOSAL CONSIDERATIONS:
Dispose of in accordance with prevailing country, federal, state and local regulations


SECTION 14. TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport

 

SECTION 15. REGULATORY INFORMATION:
Code letter and hazard designation of product:
Xi: Irritant
EU Risk And Safety phrases:
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S28: After contact with skin, wash immediately with plenty of water
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
R36/37/38: Irritating to eyes, respiratory system and skin


SECTION 16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability
Reviewed:  June 1, 2018