SECTION 1. IDENTIFICATION: Trade name: PI-103, Free Base Product Number: P-9099 Manufacturer/Supplier: LC Laboratories 165 New Boston Street Woburn, MA 01801 USA 1-781-937-0777 Fax: 1-781-938-5420
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SECTION 2. HAZARD(S) IDENTIFICATION: Hazard Description: pharmaceutically active substance that has not been fully tested May be harmful if swallowed, inhaled, or absorbed through the skin Exposure may cause irritation of the skin, eyes, mucous membranes, and upper respiratory tract Signal Word: Warning GHS Hazard Statements: H302+312+332 - Harmful if swallowed, in contact with skin or if inhaled GHS Precautionary Statements: P2562 - Do not get in eyes, on skin or on clothing WARNING: For Laboratory Research Use Only
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SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS: Chemical Name: 3-[4-(4-morpholinyl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]-phenol Synonyms: PIK-103, PI3-Kinase α Inhibitor I Hazardous Ingredient: PI-103, Free Base CAS Registry Number: 371935-74-9 Molecular Weight: 348.36 Molecular Formula: C19H16N4O3
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SECTION 4. FIRST-AID MEASURES: After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician After eye contact: check for and remove contact lenses; flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician
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SECTION 5. FIRE-FIGHTING MEASURES: Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes Unusual fire hazard: may emit toxic fumes under fire conditions such as carbon monoxide, etc.
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SECTION 6. ACCIDENTAL RELEASE MEASURES: Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves Measures for cleaning/collecting: absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13
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SECTION 7. HANDLING AND STORAGE: Information for safe handling: avoid contact with skin, eyes and clothing; material may be an irritant Storage: store solid and solutions at -20 ºC
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SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION: Personal protective equipment as follows: Breathing equipment: NIOSH/MSHA-approved respirator Protection of hands: chemical-resistant rubber gloves Eye protection: chemical safety goggles
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SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES: Form: crystalline solid; granular or powder Color: white to off-white/beige Odor: none Melting point/Melting range: 283-293 ºC Danger of explosion: none Solubility in / Miscibility with water: very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility Solvent content: Organic solvents: soluble in DMSO at 40 mg/mL; very poorly soluble in ethanol
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SECTION 10. STABILITY AND REACTIVITY: Stability: avoid acids and bases Thermal decomposition / conditions to be avoided: protect from light and heat Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide and carbon dioxide, and nitrogen oxides
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SECTION 11. TOXICOLOGICAL INFORMATION: RTECS #: not available Acute toxicity: not known Primary irritant effect: On the skin: may be an irritant; may be harmful if absorbed through the skin On the eye: may be an irritant Inhalation: may be an irritant; may be harmful if inhaled Ingestion: may be harmful if swallowed
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SECTION 12. ECOLOGICAL INFORMATION: General notes: no data available Treat as potentially toxic if released into the environment
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SECTION 13. DISPOSAL CONSIDERATIONS: Dispose of in accordance with prevailing country, federal, state and local regulations
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SECTION 14. TRANSPORT INFORMATION: DOT: Proper shipping name: none Non-Hazardous for transport: this substance is considered to be non-hazardous for transport IATA class: Proper shipping name: none Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
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SECTION 15. REGULATORY INFORMATION: Code letter and hazard designation of product: EU Risk And Safety phrases: S22: Do not breathe dust S24/25: Avoid contact with skin and eyes S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
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SECTION 16. OTHER INFORMATION: The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability Reviewed: July 1, 2019
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