Safety Data Sheet

Safety Data Sheet - LC Laboratories
Revision Date: June 1, 2018

SECTION 1. IDENTIFICATION:
Trade name: Pazopanib, Hydrochloride Salt
Product Number: P-6755
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
1-781-937-0777 Fax: 1-781-938-5420


SECTION 2. HAZARD(S) IDENTIFICATION:
Hazard Description: Reproductive effector; pharmaceutical agent
May be harmful if swallowed, inhaled, or absorbed through the skin
Exposure may impair fertility and may be harmful to a developing fetus
Ingestion may cause diarrhea, vomiting, nausea, anorexia (decreased appetite), dysgeusia (taste alteration), headache, elevated liver enzymes (ALT/AST), dyspnea (shortness of breath), hypertension (increased blood pressure), hair color changes (depigmentation), and musculoskeletal pain
Exposure may cause irritation of the respiratory tract, eye, and skin and allergic respiratory and skin reactions such as rash, urticaria (hives), and pruritus (itching)
Signal Word: Danger
GHS Hazard Statements:
H303 - May be harmful if swallowed
H313 - May be harmful in contact with skin
H333 - May be harmful if inhaled
H335 - May cause respiratory irritation
H360 - May damage fertility or the unborn child
H373 - May cause damage to organs through prolonged or repeated exposure: liver
GHS Precautionary Statements:
P201 - Obtain special instructions before use
P202 - Do not handle until all safety precautions have been read and understood
P261 - Avoid breathing dust/fume/gas/mist/vapours/spray
P264 - Wash skin thoroughly after handling
P280 - Wear protective gloves/eye protection/face protection
P308 + P311 - IF exposed or concerned: Call a POISON CENTER or doctor/physician
P314 - Get medical advice/attention if you feel unwell
P405 - Store locked up
P501 - Dispose of contents/container in accordance with local/regional/national/international regulations

 

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS:
Chemical Name: 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide Hydrochloride
Synonyms: Armala, GW-786034B, Votrient
Hazardous Ingredient: Pazopanib, Hydrochloride Salt
CAS Registry Number: 635702-64-6
Molecular Weight: 473.98
Molecular Formula: C21H23N7O2S•HCl


SECTION 4. FIRST-AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses; flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician


SECTION 5. FIRE-FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder, or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Unusual fire hazard: may emit toxic fumes under fire conditions such as carbon monoxide, etc.


SECTION 6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13


SECTION 7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC


SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: handle with Nitrile rubber gloves with minimum thickness of 0.11 mm (4.3 mil). This recommendation should not be interpreted as offering an approval for any specific use conditions. Please review this recommendation with a safety officer to evaluate if it is appropriate for the anticipated use.
Eye protection: chemical safety goggles

 

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: crystalline solid; granular or powder
Color: white to off-white
Odor: none
Melting point/Melting range: 301-313 ºC
Danger of explosion: none
Solubility in / Miscibility with water: very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum or other additives may increase or decrease the aqueous solubility
Solvent content: none
Organic solvents: soluble in DMSO at 8.3 mg/mL with slight warming; very poorly soluble in ethanol


SECTION 10. STABILITY AND REACTIVITY:
Stability: stable if stored as directed; avoid strong oxidizing agents
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides


SECTION 11. TOXICOLOGICAL INFORMATION:
RTECS #: DB2356200 (RTECS # and toxicity apply to the free base form of this compound)
Acute toxicity: in vitro toxicity (ICLo): 5 µmol/L (rat myocardium)
Primary irritant effect:
On the skin: may be an irritant; allergic skin reactions might occur following repeated contact; may be harmful if absorbed through the skin
On the eye: may be an irritant
Inhalation: may be an irritant; may be harmful if inhaled
Ingestion: may be harmful if swallowed


SECTION 12. ECOLOGICAL INFORMATION:
General notes: no data available
Treat as potentially toxic if released into the environment


SECTION 13. DISPOSAL CONSIDERATIONS:
Dispose of in accordance with prevailing country, federal, state and local regulations


SECTION 14. TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport

 

SECTION 15. REGULATORY INFORMATION:
Code letter and hazard designation of product:
EU Risk And Safety phrases:
S22: Do not breathe dust
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S53: Avoid exposure - obtain special instructions before use
R62: Possible risk of impaired fertility
R63: Possible risk of harm to the unborn child


SECTION 16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability
Reviewed:  June 1, 2018