Safety Data Sheet

SECTION 1. IDENTIFICATION
Trade name: Enasidenib, Free Base
Product Number: E-2121
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
+1-781-937-0777 Fax: +1-781-938-5420

SECTION 2. HAZARD(S) IDENTIFICATION:
Hazard Description: Toxic
RTECS Substance category:
Signal Word: Warning
GHS Hazard Statements:
H302: Harmful if swallowed
H410: Very toxic to aquatic life with long lasting effects
GHS Precautionary Statements:
P264: Wash skin thoroughly after handling
P270: Do not eat, drink or smoke when using this product
P273: Avoid release to the environment
P2562: Do not get in eyes, on skin or on clothing
P301 + P312: If swallowed: Call a POISON CENTER or doctor/ physician if you feel unwell
P330: Rinse mouth
P391: Collect spillage
P501: Dispose of contents/ container to an approved waste disposal plant
WARNING: For Laboratory Research Use Only
 

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS:
Chemical Name:
Synonyms: AG-221; AG 221; AG221; CC-90007; CC 90007; CC90007; Enasidenib, Free Base
Hazardous Ingredient: Enasidenib, Free Base
CAS Registry Number: 1446502-11-9
Molecular Weight: 473.38
Molecular Formula: C₁₉H₁₇F₆N₇O

SECTION 4. FIRST-AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses; flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; do not induce vomitting; call a physician
Most important symptoms and effects, both acute and delayed: the most important symptoms and effects are described in the labeling (see section 2)
Indication of any immediate medical attention and special treatment needed: treat symptomatically

SECTION 5. FIRE-FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Unusual fire hazard: may emit toxic fumes under fire conditions such as carbon monoxide, etc.

SECTION 6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Environmental precautions: prevent further leakage or spillage if safe to do so; do not let product enter drain
Measures for cleaning/collecting: absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13

SECTION 7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and clothing; material may be an irritant; use only in an area with proper exhuast ventilation; for precautions, see section 2
Storage: 2-8°C for short term (weeks to three months) or -20°C for long term (3 months to 3 years); keep in a cool and well-ventilated area away from direct sunlight and sources of ignition

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: handle with Nitrile rubber gloves with minimum thickness of 0.11 mm (4.3 mil); this recommendation should not be interpreted as offering an approval for any specific use conditions; please review this recommendation with a safety officer to evaluate if it is appropriate for the anticipated use
Eye protection: chemical safety goggles
Control of environmental exposure: prevent further leakage or spillage if safe to do so; do not let product enter drains

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: Solid powder
Color: white to off-white
Odor: no data available
Melting point/Melting range: no data available
Danger of explosion: no data available
Solubility in / Miscibility with water: Solvent content: Soluble in DMSO
Organic solvents: no data available

SECTION 10. STABILITY AND REACTIVITY:
Reactivity: no data available
Stability: Stable under recommended storage conditions
Possibility of hazardous reactions: no data available
Thermal decomposition / conditions to be avoided: no data available
Incompatible materials: strong acids/alkalis, strong oxidising/reducing agents
Dangerous products of decomposition: no data available

SECTION 11. TOXICOLOGICAL INFORMATION:
RTECS #: Unavailable
Acute toxicity:
Primary irritant effect: Classified on available data. For more details, see section 2.
On the eye: Classified on available data. For more details, see section 2.
Inhalation: Classified on available data. For more details, see section 2.
Ingestion: Classified on available data. For more details, see section 2.

SECTION 12. ECOLOGICAL INFORMATION:
General notes: no data available
Treat as potentially toxic if released into the environment

SECTION 13. DISPOSAL CONSIDERATIONS:
Waste treatment methods:
Product: dispose of in accordance with prevailing country, federal, state and local regulations
Contaminated packaging: dispose of in accordance with prevailing country, federal, state and local regulations

SECTION 14. TRANSPORT INFORMATION:
DOT (US): this substance is considered to be non-hazardous for transport
IATA:
UN number: 3077
Class: 9
Packing group: III
Proper shipping name: Environmentally hazardous substance, solid, n.o.s.
IMDG:
UN number: 3077
Class: 9
Packing group: III
EMS-No: F-A, S-F
Proper shipping name: Environmentally hazardous substance, solid, n.o.s.
Marine pollutant: marine pollutant

SECTION 15. REGULATORY INFORMATION:
Massachusetts Right to Know Components: No components are subject to the Massachusetts Right to Know Act
Pennslyvania Right to Know Components: No components are subject to the Pennslyvania Right to Know Act
New Jersey Right to Know Components: No components are subject to the New Jersey Right to Know Act
California Prop. 65 Components: This product does not contain any chemicals known to State of California to cause cancer, birth defects, or anyother reproductive harm

EU Risk And Safety phrases:
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves, and eye/face protection
R36/37/38: Irritating to eyes, respiratory system and skin

SECTION 16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability
Reviewed:  November 1, 2019