Safety Data Sheet

SAFETY DATA SHEET - LC LABORATORIES
REVISION DATE: JULY 1, 2019

SECTION 1. IDENTIFICATION:
Trade name: Entinostat, Free Base
Product Number: E-3866
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
1-781-937-0777 Fax: 1-781-938-5420


SECTION 2. HAZARD(S) IDENTIFICATION:
Hazard Description: Toxic; Irritant
Toxic if swallowed
May be harmful if inhaled or absorbed through the skin
Causes irritation of the skin and eyes
Toxic to aquatic organisms
Prolonged exposure may result in serious damage to health
May impair fertility and harm unborn child
Ingestion may result in anemia, thrombocytopenia (low platelet count), hypophosphatemia (low serum phosphorus), hypoalbuminemia (low serum albumin), hyponatremia (low serum sodium), hypocalcemia (low serum calcium), hypertriglyceridemia (elevated serum triglyceride level), hyperglycemia (elevated serum glucose level), headache, fatigue/lethargy, asthenia (lack of muscle strength), somnolence, weakness/unsteady gait, dyspnea (shortness of breath), nausea, vomiting, anorexia (decreased appetite, diarrhea, and infection
Exposure may cause irritation of the respiratory tract
Signal Word: Danger
GHS Hazard Statements:
H302+312+332 - Harmful if swallowed, in contact with skin or if inhaled
GHS Precautionary Statements:
P2562 - Do not get in eyes, on skin or on clothing
WARNING: For Laboratory Research Use Only


SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS:
Chemical Name: N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-carbamic acid 3-pyridinylmethyl ester
Synonyms: MS-27-275, MS 275-27, MS-275, Histone Deacetylase Inhibitor I, SNDX-275
Hazardous Ingredient: Entinostat, Free Base
CAS Registry Number: 209783-80-2
Molecular Weight: 376.41
Molecular Formula: C21H20N4O3


SECTION 4. FIRST-AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses; flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician


SECTION 5. FIRE-FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Unusual fire hazard: may emit toxic fumes under fire conditions such as carbon monoxide, etc.


SECTION 6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13


SECTION 7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC

 

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: handle with Nitrile rubber gloves with minimum thickness of 0.11 mm (4.3 mil). This recommendation should not be interpreted as offering an approval for any specific use conditions. Please review this recommendation with a safety officer to evaluate if it is appropriate for the anticipated use.
Eye protection: chemical safety goggles


SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: crystalline solid; granular or powder
Color: white to off-white
Odor: none
Melting point/Melting range: not determined
Danger of explosion: none
Solubility in / Miscibility with water: very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM buffers, serum, or other additives may increase or decrease the aqueous solubility
Solvent content:
Organic solvents: soluble in DMSO at 25 mg/mL with slight warming; very poorly soluble in ethanol


SECTION 10. STABILITY AND REACTIVITY:
Stability: avoid acids and bases
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide and carbon dioxide, and nitrogen oxides


SECTION 11. TOXICOLOGICAL INFORMATION:
RTECS #: EY8572500
Acute toxicity: oral toxicity (LD50): 380-750 mg/kg (mouse); oral toxicity (LD50): 150-200 mg/kg (rat) - toxicity data from the Bayer MSDS dated February 1, 2007 for MS-275
Primary irritant effect: not known
On the skin: causes skin irritation; may be harmful if absorbed through the skin
On the eye: causes eye irritation
Inhalation: may be an irritant; may be harmful if inhaled
Ingestion: toxic if swallowed; may result in fetal harm and impaired fertility


SECTION 12. ECOLOGICAL INFORMATION:
General notes: no data available
Treat as potentially toxic if released into the environment


SECTION 13. DISPOSAL CONSIDERATIONS:
Dispose of in accordance with prevailing country, federal, state and local regulations

 

SECTION 14. TRANSPORT INFORMATION:
UN number: 2811
DOT: Toxic solid, organic, n.o.s. (3-Pyridylmethyl N-{4-[(2-aminophenyl)carbamoyl]benzyl}carbamate) Class: 6.1, Packing group: III
IMDG: Toxic solid, organic, n.o.s. (3-Pyridylmethyl N-{4-[(2-aminophenyl)carbamoyl]benzyl}carbamate) Class: 6.1, Packing group: III
IATA: Toxic solid, organic, n.o.s. (3-Pyridylmethyl N-{4-[(2-aminophenyl)carbamoyl]benzyl}carbamate) Class: 6.1, Packing group: III


SECTION 15. REGULATORY INFORMATION:
Code letter and hazard designation of product:
T: Toxic; XI: Irritant
EU Risk And Safety phrases:
S22: Do not breathe dust
S36/37: Wear suitable protective clothing and gloves
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
R25: Toxic if swallowed
R36/38: Irritating to eyes and skin
R48/25: Toxic: danger of serious damage to health by prolonged exposure if swallowed
R61: May cause harm to the unborn child
R62: Possible risk of impaired fertility


SECTION 16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability
Reviewed:  July 1, 2019