Monday 27 June 2022 - 11:12
In Business 42 Years - Since 1980
Reminder: Genuine LC Laboratories® brand PMA, which we have been manufacturing in the U.S. for more
than 40 years, is available directly from us: Cat No. P-1680 Phorbol 12-Myristate 13-Acetate, >99.5%.
Our PMA is also available from our >50 U.S. and international distributors, and from more than a dozen
major biochemical reagent "resellers" (who sell our PMA under their own brand names and labels)
FREE SHIPPING TO THE U.S. AND 32 OTHER COUNTRIES! [Read more].
H-5239 H-89, Dihydrochloride Salt, >99%
- Size
- US $
- €
- £
- ¥
- 10 mg
- 57
- 53
- 46
- 7,700
- In stock
- 25 mg
- 119
- 112
- 96
- 16,100
- In stock
- 100 mg
- 399
- 377
- 323
- 53,900
- In stock
Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
- M.W. 519.28
- C20H20BrN3O2S•2HCl
- [130964-39-5]
Storage: Store desiccated at or below -20 ºC. Solubility: Soluble in DMSO at 100 mg/ml; soluble in ethanol at 2 mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 pM; buffers, serum or other additives may increase or decrease the aqueous solubility. Disposal: A.
- Potent and selective inhibitor of PKA, with an IC50 of about 50 nM. Chijiwa, T., et al. "Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells." J. Biol. Chem. 265: 5267-5272 (1990).
- Also inhibits PKG and the µ isotype of PKC (at about 500 nM). In contrast, most other PKC isotypes are much more weakly inhibited, with IC50's in the 32 µM range. Johannes, F.-J., Prestle, J., Dieterich, S., Oberhagemann, P., Link, G. and Pfizenmaier, K. "Characterization of activators and inhibitors of protein kinase Cµ." Eur. J. Biochem. 227: 303-307 (1995).
- Please request Technical Note #24 for additional information.
- Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
