H-5239 H-89, Dihydrochloride Salt, >99%

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  • M.W. 519.28
  • C20H20BrN3O2S•2HCl
  • [130964-39-5]

Storage: Store desiccated at or below -20 ºC. Solubility: Soluble in DMSO at 100 mg/ml; soluble in ethanol at 2 mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 pM; buffers, serum or other additives may increase or decrease the aqueous solubility. Disposal: A.

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  • Potent and selective inhibitor of PKA, with an IC50 of about 50 nM. Chijiwa, T., et al. "Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells." J. Biol. Chem. 265: 5267-5272 (1990).
  • Also inhibits PKG and the µ isotype of PKC (at about 500 nM). In contrast, most other PKC isotypes are much more weakly inhibited, with IC50's in the 32 µM range. Johannes, F.-J., Prestle, J., Dieterich, S., Oberhagemann, P., Link, G. and Pfizenmaier, K. "Characterization of activators and inhibitors of protein kinase Cµ." Eur. J. Biochem. 227: 303-307 (1995).
  • Please request Technical Note #24 for additional information.
  • Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
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