A-1040 Ascomycin, >99%

Synonyms : [FK-520] [FR-900520] [L 683590]

Related Terms : [Immunomycin]

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  • 25 mg
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  • M.W. 792.01
  • C43H69NO12
  • [104987-12-4]

Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 65 mg/mL; soluble in ethanol at 50 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM; buffers, serum, or other additives may increase or decrease the aqueous solubilit. Disposal: A.

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  • Ascomycin (also known as Immunomycin, FR-900520, and FK-520) is an analog of tacrolimus (FK-506) with immunosuppressive, neurotrophic and antifungal activities. Ascomycin can be used to prevent rejection after an organ transplant, and to treat autoimmune diseases and skin diseases.
  • Ascomycin inhibits the production of T helper type 1 (Th1) (interferon and IL-2) and Th2 (IL-4 and IL-10) cytokines in target cells. Paul, C., et al. "Ascomycins: promising agents for the treatment of inflammatory skin diseases." Expert Opin. Investig. Drugs. 9: 69-77 (2000). Mollison, K.W., et al. "A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases." J. Invest. Dermatol. 112: 729-738 (1999).
  • Antimalarial effects of ascomycin appear to be independent of its immunosuppressive properties. Monaghan, P., et al. "Antimalarial effects of macrolactones related to FK520 (ascomycin) are independent of the immunosuppressive properties of the compounds." J. Infect. Dis. 191: 1342-1349 (2005).
  • FK-520 might be a substrate for P-glycoprotein; expression of P-glycoprotein in yeast cells resulted in resistance to growth inhibition by FK-520. Raymond, M., et al. "Functional expression of P-glycoprotein in Saccharomyces cerevisiae confers cellular resistance to the immunosuppressive and antifungal agent FK520." Mol. Cell Biol. 14: 277-286 (1994).
  • Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
  • Please see also our other standard immunosuppressant products:
    C-6000 Cyclosporin A
    E-4040 Everolimus
    F-4633 Fingolimod Hydrochloride Salt
    F-4900 FK-506
    R-5000 Rapamycin
    T-8040 Temsirolimus
    T-1377 Tofacitinib, Free Base
    T-1399 Tofacitinib,Citrate

  • We note that one of our competitors, AG Scientific, as of February 3, 2014, is claiming 99.9% purity for its Ascomycin. This claim is not credible in general chemical terms for this complex organic compound, nor in terms of the sensitivity and reproducibility of generally utilized analytical techniques.