B-2332 Binimetinib, Free Base, >99%

Synonyms : [ARRY438162] [ARRY-162] [MEK162]

Related Terms : [Mektovi]

  • Size
  • US $
  • €
  • £
  • ¥
  • 25 mg
  • 49
  • 40
  • 35
  • 5,100
  • Add to Cart Qty:
  • In stock
  • 50 mg
  • 72
  • 59
  • 52
  • 7,500
  • Add to Cart Qty:
  • In stock
  • 100 mg
  • 112
  • 92
  • 81
  • 11,600
  • Add to Cart Qty:
  • In stock
  • 200 mg
  • 189
  • 155
  • 138
  • 19,600
  • Add to Cart Qty:
  • In stock
  • 500 mg
  • 339
  • 279
  • 247
  • 35,200
  • Add to Cart Qty:
  • In stock
  • 1 g
  • 641
  • 528
  • 468
  • 66,500
  • Add to Cart Qty:
  • In stock

Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.

To receive a Formal Quotation for catalog sizes of this product and/or any other products, please add them to your shopping cart and click on the “REQUEST A QUOTATION” box.
Click Here to Request a Quotation for Larger Quantities Free Shipping and Handling to the U.S. and 33 Other Countries
Compare Quality and Prices — LC Labs vs. Other Suppliers
  • M.W. 441.23
  • C17H15BrF2N4O3
  • [606143-89-9]

Solubility: Soluble in DMSO.

Select Lot Number to view Certificate of Analysis

View the SDS for this product

  • Binimetinib, also known as MEK162, is a novel, second generation MEK1/2 inhibitor. N-RAS mutant melanoma cultures appeared to be particularly sensitive to binimetinib, which reduced ERK1/2 phosphorylation, induced apoptosis, and significantly reduced clonogenic survival. Thumar, J. et al., "MEK targeting in N-RAS mutated metastatic melanoma." Mol. Cancer 13: 45 (2014).
  • Binimetinib induced transient retinopathy with multiple bilateral lesions in some patients with metastatic melanoma. Urner-Bloch, U. et al., "Transient MEK inhibitor-associated retinopathy in metastatic melanoma." Ann. Oncol. 25: 1437-1441 (2014).
  • Binimetinib showed some activities in patients with advanced melanoma harboring NRAS or Val600 BRAF mutations in a open-label, non-randomised, phase 2 study. Ascierto, P.A. et al., "MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study." Lancet Oncol. 14: 249-256 (2013).
  • Other CAS numbers previously assigned to binimetinib, free base, namely 1073666-70-2, 1201685-05-3, and 1417448-81-7, have been deleted by CAS and are no longer in use.
  • Binimetinib is the active ingredient in the drug product sold under the trade name Mektovi®. This drug is currently approved in at least one country for use, in combination with encorafenib, for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation.  NOTE: THE BINIMETINIB SOLD BY LC LABORATORIES FOR RESEARCH IS NOT MEKTOVI®, AND IS NOT FOR HUMAN USE.
  • Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.
  • This product is offered for R&D use in accordance with (i) 35 USC 271(e)+A13(1) in the U.S.; (ii) Section 69.1 of Japanese Patent Law in Japan; (iii) Section 11, No. 2 of the German Patent Act of 1981 in Germany; (iv) Section 60, Paragraph 5b of the U.K. Patents Act of 1977 in the U.K.; (v) Sections 55.2(1) and 55.2(6) and other common law exemptions of Canadian patent law; (vi) Section 68B of the Patents Act of 1953 in New Zealand together with the amendment of same by the Statutes Amendment Bill of 2002; (vii) such related legislation and/or case law as may be or become applicable in the aforementioned countries; and (viii) such similar laws and rules as may apply in various other countries.
  • Not available in some countries; not available to some institutions; not available for some uses.
1865