B-8500 Brefeldin A, >99%

Synonyms : [BFA]

Related Terms : [Ascotoxin] [Cyanein] [Decumbin] [Nectrolide] [Synergisidin]

  • Size
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  • 10 mg
  • 67
  • 61
  • 54
  • 7,300
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  • In stock
  • 25 mg
  • 95
  • 87
  • 76
  • 10,300
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  • 50 mg
  • 176
  • 162
  • 141
  • 19,100
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  • 100 mg
  • 277
  • 255
  • 223
  • 30,100
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  • In stock
  • 300 mg
  • 735
  • 676
  • 592
  • 79,900
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  • In stock

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  • M.W. 280.36
  • C16H24O4
  • [20350-15-6]
  • M.I. 11: 1363
  • M.I. 14: 1369

Warnings: Toxic.

Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 100 mg/mL; soluble in ethanol at 25 mg/mL with slight warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 µM; buffers, serum, or other additives may increase or decrease the aqueous s. Disposal: A.

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  • More than 300 labs worldwide have purchased Brefeldin A from LC Labs (either directly from us or from our many distributors, many of whom resell under their own labels).
  • Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus. Misumi, Y., et al. "Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes." J. Biol. Chem. 261: 11398-11403 (1986).
  • Brefeldin A has been shown to induce apoptosis in human tumor cells via a process requiring caspase activation. Guo, H., et al. "Brefeldin A-mediated apoptosis requires the activation of caspases and is inhibited by Bcl-2." Exp. Cell Res. 245: 57-68 (1998).
  • Brefeldin A has been identified as an activator of the sphingomyelin signal transduction cycle. Linardic, C. M., et al. "Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking." Cell Growth Differ. 7: 765-774 (1996). Alessenko, A.V. "The role of sphingomyelin cycle metabolites in transduction of signals of cell proliferation, differentiation and death." Membr. Cell Biol. 13: 303-320 (2000).
  • Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
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