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B-8500 Brefeldin A, >99%
Synonyms : [BFA]
Related Terms : [Ascotoxin] [Cyanein] [Decumbin] [Nectrolide] [Synergisidin]
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- 10 mg
- 55
- 48
- 41
- 6,200
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- Out of stock
- 25 mg
- 78
- 68
- 58
- 8,800
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- Out of stock
- 50 mg
- 143
- 126
- 107
- 16,200
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- Out of stock
- 100 mg
- 232
- 205
- 173
- 26,300
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- Out of stock
- 300 mg
- 591
- 522
- 442
- 67,000
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- Out of stock
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- M.W. 280.36
- C16H24O4
- [20350-15-6]
- M.I. 11: 1363
- M.I. 14: 1369
Warnings: Toxic.
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 100 mg/mL; soluble in ethanol at 25 mg/mL with slight warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 µM; buffers, serum, or other additives may increase or decrease the aqueous s. Disposal: A.
- More than 300 labs worldwide have purchased Brefeldin A from LC Labs (either directly from us or from our many distributors, many of whom resell under their own labels).
- Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus. Misumi, Y., et al. "Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes." J. Biol. Chem. 261: 11398-11403 (1986).
- Brefeldin A has been shown to induce apoptosis in human tumor cells via a process requiring caspase activation. Guo, H., et al. "Brefeldin A-mediated apoptosis requires the activation of caspases and is inhibited by Bcl-2." Exp. Cell Res. 245: 57-68 (1998).
- Brefeldin A has been identified as an activator of the sphingomyelin signal transduction cycle. Linardic, C. M., et al. "Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking." Cell Growth Differ. 7: 765-774 (1996). Alessenko, A.V. "The role of sphingomyelin cycle metabolites in transduction of signals of cell proliferation, differentiation and death." Membr. Cell Biol. 13: 303-320 (2000).
- Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
