D-8147 Duvelisib, Free Base, >99%

Synonyms : [IPI-145] [INK-1197]

Related Terms : [Copiktra]

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  • 5 mg
  • 49
  • 45
  • 38
  • 7,800
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  • 10 mg
  • 75
  • 70
  • 59
  • 12,000
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  • 25 mg
  • 119
  • 111
  • 94
  • 19,000
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  • 50 mg
  • 162
  • 151
  • 127
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  • 100 mg
  • 218
  • 203
  • 172
  • 34,800
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  • 200 mg
  • 359
  • 335
  • 283
  • 57,400
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  • 500 mg
  • 722
  • 674
  • 570
  • 115,400
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  • M.W. 416.86
  • C22H17ClN6O
  • [1201438-56-3]

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  • Duvelisib, also known as IPI-145, is a potent inhibitor of phosphoinositide-3-kinase (PI3K) [delta] and PI3K [gamma]. It inhibits PI3K [delta] and [gamma] with Ki values of 23 and 243 pM, cell-free IC50 values of 2.5 and 27.4 nM, and cellular IC50 values of 1 nM and 43 nM, respectively. It was active in preclinical models of arthritis. Porter J.R., et al. "The potent phosphoinositide-3-kinase-(delta, gamma) inhibitor IPI-145 is active in preclinical models of arthritis and well tolerated in healthy adult subjects." http://infi.com/pdfs/ACR_ARHP2012.pdf
  • Duvelisib was active and well-tolerated in patients with relapsed/refractory peripheral and cutaneous T-cell lymphomas. Horwitz S., et al. "Preliminary Safety and Efficacy of IPI-145, a Potent Inhibitor of Phosphoinositide-3-Kinase-δ, γ in Patients with Relapsed/Refractory T-Cell Lymphoma." http://infi.com/pdfs/LuganoTcell.pdf
  • A phase I trial demonstrated that duvelisib was well tolerated and showed initial clinical activity in patients with indolent non-Hodgkin's lymphoma, mantle cell lymphoma, and chronic lymphocytic leukemia. Flinn I.W., et al. "Clinical Safety and Activity in a Phase 1 Trial of IPI-145, a Potent Inhibitor of Phosphoinositide-3-Kinase-{delta},{gamma}, in Patients with Advanced Hematologic Malignancies." Blood (ASH Annual Meeting Abstracts) 120: Abstract 3663 (2012).
  • Other CAS numbers previously assigned to IPI-145 free base, namely 1355213-59-0 and 1428465-12-6, have been deleted by CAS and are no longer in use.
  • Duvelisib is the active ingredient in the drug product sold under the trade name Copiktra®.  This drug is currently approved in at least one country for the treatnent of adult patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma.  NOTE: THE DUVELISIB SOLD BY LC LABORATORIES FOR RESEARCH IS NOT COPIKTRA®, AND IS NOT FOR HUMAN USE.
  • Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.
  • This product is offered for R&D use in accordance with (i) 35 USC 271(e)+A13(1) in the U.S.; (ii) Section 69.1 of Japanese Patent Law in Japan; (iii) Section 11, No. 2 of the German Patent Act of 1981 in Germany; (iv) Section 60, Paragraph 5b of the U.K. Patents Act of 1977 in the U.K.; (v) Sections 55.2(1) and 55.2(6) and other common law exemptions of Canadian patent law; (vi) Section 68B of the Patents Act of 1953 in New Zealand together with the amendment of same by the Statutes Amendment Bill of 2002; (vii) such related legislation and/or case law as may be or become applicable in the aforementioned countries; and (viii) such similar laws and rules as may apply in various other countries.
  • Not available in some countries; not available to some institutions; not available for some uses.