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F-4900 FK-506, >99%
Related Terms : [FR-900506] [Fujimycin] [Prograf] [Tacrolimus]
- Size
- US $
- €
- £
- ¥
- 50 mg
- 64
- 54
- 47
- 7,100
- In stock
- 100 mg
- 113
- 95
- 83
- 12,500
- In stock
- 200 mg
- 166
- 140
- 122
- 18,300
- In stock
- 500 mg
- 252
- 213
- 186
- 27,800
- In stock
- 1 g
- 365
- 309
- 269
- 40,300
- In stock
- 2 g
- 616
- 522
- 455
- 67,900
- In stock
- 5 g
- 1,120
- 949
- 827
- 123,500
- In stock
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- M.W. 804.02
- C44H69NO12
- [104987-11-3]
- M.I. 13: 9117
- M.I. 14: 9025
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 100 mg/mL; soluble in ethanol at 100 mg/mL; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A.
- Ascomycin level is less than 0.5%.
- FK-506 is a potent immunosuppressant and in vitro T cell proliferation blocker. It has been shown to disrupt calcineurin (also known as CaN or phosphatase 2B)-mediated signal transduction in T lymphocytes. The compound interacts with its FK506-binding protein-12 (FKBP12). The resulting complex, in turn, interferes with calcineurin substrate interaction. Dumont, F.J. "FK506, an immunosuppressant targeting calcineurin function." Curr. Med. Chem. 7: 731-748 (2000).
- FK-506 inhibits FKBP activity resulting in an increase in the release of sarcoplasmic reticulum-derived calcium. FK-506 also appears to inhibit Na(+)-Ca2+ exchange. Unlike rapamycin, which also binds to FK506-binding protein-12, FKBP12 with or without bound FK506 has no effect on rat brain PKC activity in vitro. McCall, E., et al. "Effects of FK-506 on contraction and Ca2+ transients in rat cardiac myocytes." Circ. Res. 79: 1110-1121 (1996). Rokaw, M.D., et al. "Rapamycin inhibits protein kinase C activity and stimulates Na+ transport in A6 cells." J. Biol. Chem. 271: 32468-32473 (1996).
- Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
- Please see also our other standard immunosuppressant products:
C-6000 Cyclosporin A
E-4040 Everolimus
F-4633 Fingolimod, Hydrochloride Salt
R-5000 Rapamycin
T-8040 Temsirolimus
T-1377 Tofacitinib, Free Base
Z-9040 Zotarolimus - The CAS number for the anhydrous form of FK-506 is given above. The CAS number for FK-506 monohydrate is 109581-93-3.
- FK-506 (Tacrolimus) is the active ingredient in the drug sold under the trade names Fujimycin® and Prograf®. NOTE: THE FK-506 (TACROLIMUS) RESEARCH COMPOUND SOLD BY LC LABORATORIES IS NOT FUJIMYCIN® NOR PROGRAF® AND IS NOT FOR HUMAN USE.
