F-4900 FK-506, >99%

Synonyms : [FR-900506]

Related Terms : [Fujimycin] [Prograf] [Tacrolimus]

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  • 50 mg
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  • 51
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  • In stock
  • 100 mg
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  • 78
  • 11,100
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  • 200 mg
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  • 500 mg
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  • 196
  • 174
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  • 1 g
  • 347
  • 285
  • 253
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  • 2 g
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  • 482
  • 427
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  • 5 g
  • 1,065
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  • 778
  • 110,400
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  • M.W. 804.02
  • C44H69NO12
  • [104987-11-3]
  • M.I. 13: 9117
  • M.I. 14: 9025

Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 100 mg/mL; soluble in ethanol at 100 mg/mL; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A.

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View the SDS for this product

  • More than 920 labs worldwide have purchased FK-506 from LC Labs (either directly from us or from our many distributors, many of whom resell under their own labels).
  • Ascomycin level is less than 0.9%.
  • FK-506 is a potent immunosuppressant and in vitro T cell proliferation blocker. It has been shown to disrupt calcineurin (also known as CaN or phosphatase 2B)-mediated signal transduction in T lymphocytes. The compound interacts with its FK506-binding protein-12 (FKBP12). The resulting complex, in turn, interferes with calcineurin substrate interaction. Dumont, F.J. "FK506, an immunosuppressant targeting calcineurin function." Curr. Med. Chem. 7: 731-748 (2000).
  • FK-506 inhibits FKBP activity resulting in an increase in the release of sarcoplasmic reticulum-derived calcium. FK-506 also appears to inhibit Na(+)-Ca2+ exchange. Unlike rapamycin, which also binds to FK506-binding protein-12, FKBP12 with or without bound FK506 has no effect on rat brain PKC activity in vitro. McCall, E., et al. "Effects of FK-506 on contraction and Ca2+ transients in rat cardiac myocytes." Circ. Res. 79: 1110-1121 (1996). Rokaw, M.D., et al. "Rapamycin inhibits protein kinase C activity and stimulates Na+ transport in A6 cells." J. Biol. Chem. 271: 32468-32473 (1996).
  • Water content of LC Labs' F-4900, FK506:
    PLEASE NOTE: We do not attempt or purport to control the water content of our FK-506 product.  We use the CAS number assigned to the anhydrous form.

    Here are the water levels of our most recent lots, as determined by elemental analysis:
    ATH-123   0.9 eq
    ATH-122   0.9 eq
    ATH-121   1.0 eq
    ATH-120   1.0 eq
    ATH-119   none
    ATH-118   0.8 eq
    ATH-117   0.8 eq
    ATH-116   0.8 eq
  • Drying compounds to the point of complete absence of water is often a completely futile exercise, because many organic compounds rapidly rehydrate when opened to the air, even for short periods of time, in normal use.  The rate and avidity of such re-hydration is sometimes very impressive, indeed awesome in some cases, even for compounds that are not generally recognized as being hydroscopic.
  • Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
  • Please see also our other standard immunosuppressant products:
    A-1040 Ascomycin
    C-6000 Cyclosporin A
    E-4040 Everolimus
    F-4633 Fingolimod Hydrochloride Salt
    R-5000 Rapamycin
    T-8040 Temsirolimus
    T-1377 Tofacitinib, Free Base
    T-1399 Tofacitinib,Citrate

  • The CAS number for the anhydrous form of FK-506 is given above. The CAS number for FK-506 monohydrate is 109581-93-3.
  • FK-506 (Tacrolimus) is the active ingredient in the drug sold under the trade names Fujimycin® and Prograf®. NOTE: THE FK-506 (TACROLIMUS) RESEARCH COMPOUND SOLD BY LC LABORATORIES IS NOT FUJIMYCIN® NOR PROGRAF® AND IS NOT FOR HUMAN USE.