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In Business 44 Years - Since 1980
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G-1111 GW7647, Free Acid, >99%
- Size
- US $
- €
- £
- ¥
- 1 mg
- 35
- 32
- 28
- 5,400
- In stock
- 5 mg
- 49
- 45
- 39
- 7,600
- In stock
- 10 mg
- 79
- 74
- 63
- 12,200
- In stock
- 25 mg
- 146
- 136
- 117
- 22,600
- In stock
- 50 mg
- 259
- 242
- 209
- 40,100
- In stock
- 100 mg
- 374
- 350
- 302
- 57,800
- In stock
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- M.W. 502.75
- C29H46N2O3S
- [265129-71-3]
Solubility: DMSO.
- GW7647 is a peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist. A synergistic antinociceptive interaction between the endogenous cannabinoid receptor agonist anandamide and GW7647 was demonstrated in a model of acute chemical-induced pain. Russo R., et al. "Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647." Eur. J. Pharmacol. 566(1-3): 117-119 (2007).
- GW7647 promoted cholesterol efflux and ATP binding cassette transporter A1/G1 expression in primary macrophages. Nakaya K., et al. "Peroxisome proliferator-activated receptor-α activation promotes macrophage reverse cholesterol transport through a liver X receptor-dependent pathway." Arterioscler. Thromb. Vasc. Biol. 31(6): 1276-1282 (2011).
- GW7647 increased the production of high-density lipoprotein and decreased cholesterol esterification in Caco-2/TC7 cells. Colin S., et al. "Activation of intestinal peroxisome proliferator-activated receptor-α increases high-density lipoprotein production." Eur. Heart J. 34(32): 2566-2574 (2013).
- Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.
- This product is offered for R&D use in accordance with (i) 35 USC 271(e)+A13(1) in the U.S.; (ii) Section 69.1 of Japanese Patent Law in Japan; (iii) Section 11, No. 2 of the German Patent Act of 1981 in Germany; (iv) Section 60, Paragraph 5b of the U.K. Patents Act of 1977 in the U.K.; (v) Sections 55.2(1) and 55.2(6) and other common law exemptions of Canadian patent law; (vi) Section 68B of the Patents Act of 1953 in New Zealand together with the amendment of same by the Statutes Amendment Bill of 2002; (vii) such related legislation and/or case law as may be or become applicable in the aforementioned countries; and (viii) such similar laws and rules as may apply in various other countries.
- Not available in some countries; not available to some institutions; not available for some uses.
