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I-5700 Ionomycin, Free Acid, >99%
- Size
- US $
- €
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- 1 mg
- 17
- 16
- 13
- 2,500
- Add to Cart
- Out of stock
- 5 mg
- 79
- 74
- 64
- 11,800
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- Out of stock
- 10 mg
- 146
- 137
- 119
- 21,800
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- Out of stock
- 25 mg
- 298
- 281
- 244
- 44,500
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- Out of stock
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- M.W. 709.00
- C41H72O9
- [56092-81-0]
Warnings: Toxic.
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A.
- July 27, 2023: Ionomycin, Free Acid is on long term backorder and has not yet been scheduled in our production queue.
- Antibiotic that acts as a potent and selective calcium ionophore; more effective than A23187. Ionomycin binds Ca2+ in the 7.0-9.5 pH range with the resulting complex exhibiting intense UV absorption. Liu, C. and Hermann T.E. "Characterization of ionomycin as a calcium ionophore." J. Biol. Chem. 253: 5892-5894 (1978). Kauffman, R.F., et al. "Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria." J. Biol. Chem. 255: 2735-2739 (1980).
- Ionomycin induces apoptosis in immature B cell lines, for example, in Burkitt lymphoma cells, and in cultured embryonic rat cortical neurons. More mature B cell lines do not undergo apoptosis, but are arrested in the G1 phase of the cell cycle. Takei, N. and Endo, Y. "Ca2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons." Brain Res. 652: 65-70 (1994). Aagaard-Tillery, K.M., et al. "Differential activation of a calcium-dependent endonuclease in human B lymphocytes. Role in ionomycin-induced apoptosis." J. Immunol. 155: 3297-3307 (1995).
- Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
