Wednesday 27 September 2023 - 00:14
In Business 43 Years - Since 1980
NOTE: all of our usual telephone and FAX systems are currently down due to a dispute between our landlord and Verizon. We are working to remedy this situation and get our phones back on ASAP.
In the meantime, please use this mobile phone number: 978-715-9327, and this fax number: 781-491-0695.
Thank you for your patience as we work through this unfortunate outage caused by a dispute beyond our control.
Sale: 25% Off !!
For Online Shopping Cart Orders Only
In-Stock Sizes Only - Limited Time Only
See Check-out Page For Further Details
FREE SHIPPING TO THE U.S. AND 32 OTHER COUNTRIES! [Read more].
K-2151 K252a, >99%
- Size
- US $
- €
- £
- ¥
- 5 mg
- 74
- 69
- 60
- 11,000
- Add to Cart
- Out of stock
- 10 mg
- 119
- 112
- 97
- 17,700
- Add to Cart
- Out of stock
- 25 mg
- 246
- 231
- 201
- 36,600
- Add to Cart
- Out of stock
- 50 mg
- 414
- 390
- 339
- 61,600
- Add to Cart
- Out of stock
- 100 mg
- 662
- 624
- 542
- 98,600
- Add to Cart
- Out of stock
- 250 mg
- 1,185
- 1,117
- 971
- 176,400
- Add to Cart
- Out of stock
- 500 mg
- 1,780
- 1,678
- 1,459
- 265,000
- Add to Cart
- Out of stock
Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
- M.W. 467.47
- C27H21N3O5
- [97161-97-2]
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 100 mg/mL; poorly soluble in ethanol. Disposal: A.
- K252a is a kinase inhibitor that inhibits PKA (Ki = 18 nM), PKC (Ki = 25 nM), and PKG (Ki = 20 nM). Kase, H., et al. "K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases." Biochem. Biophys. Res. Commun. 142: 436-440 (1987).
- Potently inhibits CaMK (Ki = 1.8 nM), competitively with ATP and noncompetitively with the substrate. Hashimoto, Y., et al. "Potent and preferential inhibition of Ca2+/calmodulin-dependent protein kinase II by K252a and its derivative, KT5926." Biochem. Biophys. Res. Commun. 181: 423-429 (1991).
- Potently inhibits phosphorylase kinase (IC50 = 1.7 nM), with 300-fold selectivity for this enzyme over protein kinase C. Elliott, L.H., et al. "K252a is a potent and selective inhibitor of phosphorylase kinase." Biochem. Biophys. Res. Commun. 171: 148-154 (1990).
- Potent inhibitor of the tyrosine phosphorylation of p140prototrk; K252a also has a direct effect on the p140prototrk tyrosine kinase. Berg, M.M., et al. "K-252a Inhibits Nerve Growth Factor-induced trk Proto-oncogene Tyrosine Phosphorylation and Kinase Activity." J. Biol. Chem. 267: 13-16 (1992).
- Potent inhibitor of pp42/44 MAP kinase in vitro and in vivo. Lloyd, E.D. and Wooten, M.W. "pp42/44MAP kinase is a component of the neurogenic pathway utilized by nerve growth factor in PC12 cells." J. Neurochem. 59: 1099-1109 (1992).
- K252a apparently induces apoptosis by suppressing phosphorylation of Rb, upregulating p21, and inhibiting Cdc2 and Cdc25c activity. Mohri, T., et al. "K252a induces cell cycle arrest and apoptosis by inhibiting Cdc2 and Cdc25c." Cancer Invest. 17: 391-395 (1999).
- Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
- We note that one of our competitors, AG Scientific, as of February 11, 2014, is claiming 99.86% purity for its K252a. This claim is not credible in general chemical terms for this complex organic compound, nor in terms of the sensitivity and reproducibility of generally utilized analytical techniques.
