N-3883 Nelfinavir, Methanesulfonate Salt, >99%

Synonyms : [AG-1343]

Related Terms : [Nelfin] [Viracept ]

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  • 10 mg
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  • 25 mg
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  • 200 mg
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  • 500 mg
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  • 1 g
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  • M.W. 663.89
  • C32H45N3O4SCH4O3S
  • [159989-65-8]

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  • Nelfinavir, also known as AG1343, is a human immunodeficiency virus (HIV) type 1 protease inhibitor (Ki = 2 nM). It had anti-HIV activities in vitro with EC50 values of 30-60 nM. Zhang K.E., et al. "Circulating metabolites of the human immunodeficiency virus protease inhibitor nelfinavir in humans: structural identification, levels in plasma, and antiviral activities." Antimicrob. Agents Chemother. 45: 1086-1093 (2001).
  • "AG1343" is the correct synonym for nelfinavir. We note that, as of September 3, 2016, Adipogen, Biomol GmbH, Chemscene, Medchem Express, Nacalai, USA, Namiki, R&D Systems, Tocris, Toronto Research Chemicals and possibly other vendors are incorrectly using "AG1341" as a synonym for nelfinavir. In addition, Abmole is using the incorrect AG1341 in the header code of its web page but the correct AG1343 in the body of the page itself.
  • Nelfinavir has been widely used with other anti-HIV drugs for the treatment of HIV infection. It has shown prolonged viral suppression, good tolerability and a unique resistance profile. Olmo M. and Podzamczer D. "A review of nelfinavir for the treatment of HIV infection." Expert Opin. Drug Metab. Toxicol. 2: 285-300 (2006).
  • Nelfinavir also has efficacy against cancer, malaria, tuberculosis, and SARS. Brüning A., et al. "New prospects for nelfinavir in non-HIV-related diseases." Curr. Mol. Pharmacol. 3: 91-97 (2010).
  • Nelfinavir has direct antitumor effects. It reduces angiogenesis and cell invasion, inhibits the Akt pathway, induces autophagy, and promotes apoptosis of cancer cells. Gantt S., et al. "Insights into the broad cellular effects of nelfinavir and the HIV protease inhibitors supporting their role in cancer treatment and prevention." Curr. Opin. Oncol. 25: 495-502 (2013).
  • Related CAS numbers: 159989-64-7 for the free base; 166734-22-1 for the maleate salt; 1402137-51-2 for the sulfate salt, ratio not specified; 865354-86-5 for the hydrate, ratio not specified.
  • Nelfinavir Methanesulfonate Salt is the active ingredient in the drug product sold under the trade name Viracept®. This drug is currently approved in at least one country for use in patients with HIV in combination with other antiretroviral drugs. NOTE: THE NELFINAVIR, METHANESULFONATE SOLD BY LC LABORATORIES FOR RESEARCH IS NOT VIRACEPT®, AND IS NOT FOR HUMAN USE.
  • Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.
  • This product is offered for R&D use in accordance with (i) 35 USC 271(e)+A13(1) in the U.S.; (ii) Section 69.1 of Japanese Patent Law in Japan; (iii) Section 11, No. 2 of the German Patent Act of 1981 in Germany; (iv) Section 60, Paragraph 5b of the U.K. Patents Act of 1977 in the U.K.; (v) Sections 55.2(1) and 55.2(6) and other common law exemptions of Canadian patent law; (vi) Section 68B of the Patents Act of 1953 in New Zealand together with the amendment of same by the Statutes Amendment Bill of 2002; (vii) such related legislation and/or case law as may be or become applicable in the aforementioned countries; and (viii) such similar laws and rules as may apply in various other countries.
  • Not available in some countries; not available to some institutions; not available for some uses.