Thursday 18 August 2022 - 18:37
In Business 42 Years - Since 1980
PLEASE NOTE: During August 2022 we are doing a comprehensive revision of our customer service workflow. This includes training of current and new personnel. We are expecting that these changes will have only very minimal effects on our overall order processing and shipping activities. However, we do ask any customers who prefer that their shipments go out on Fridays to contact our Customer Service group and let them know about your preferences in advance. Thank you.
Reminder: Genuine LC Laboratories® brand PMA, which we have been manufacturing in the U.S. for more
than 40 years, is available directly from us: Cat No. P-1680 Phorbol 12-Myristate 13-Acetate, >99.5%.
Our PMA is also available from our >50 U.S. and international distributors, and from more than a dozen
major biochemical reagent "resellers" (who sell our PMA under their own brand names and labels)
FREE SHIPPING TO THE U.S. AND 32 OTHER COUNTRIES! [Read more].
P-1680 Phorbol 12-Myristate 13-Acetate, >99.5%
Synonyms : [Cocarcinogen A1] [12-O-Tetradecanoyl-phorbol 13-Acetate] [PMA] [TPA]
- Size
- US $
- €
- £
- ¥
- 1 mg
- 39
- 38
- 32
- 5,300
- In stock
- 5 mg
- 107
- 105
- 88
- 14,400
- In stock
- 10 mg
- 199
- 196
- 165
- 26,900
- In stock
- 25 mg
- 397
- 391
- 329
- 53,600
- In stock
Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
- M.W. 616.83
- C36H56O8
- [16561-29-8]
- M.I. 12: 7487
- M.I. 14: 7332
Warnings: Highly irritant to skin and mucous membranes. SPECIAL HAZARD: TUMOR PROMOTER. Gloves and mask should be worn when using this compound. Care must be taken to prevent contact through all routes of exposure.
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO or ethanol. Disposal: A.
- LC Labs has been a primary worldwide supplier of PMA for laboratory research for more than 40 years
- More than 330,000 vials of our PMA have been used by many thousands of labs since 1980
- More than a dozen of the world's best-known biochemical reagent vendors resell our PMA under their own label
- This is the most commonly used phorbol ester. It binds to and activates protein kinase C, causes an extremely wide range of effects in cells and tissues, and is a very potent mouse skin tumor promoter. Blumberg, P.M. "In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1." Crit. Rev. Toxicol. 8: 153-197 (1980) and Blumberg, P.M. "In vitro studies on the mode of action of the phorbol esters, potent tumor promoters, part 2." Crit. Rev. Toxicol. 8: 199-234 (1980).
- Although PMA is quite toxic, it has shown anti-leukemic and anti-neutropenic activity in humans. Han, Z.T. et al. "Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia: preliminary studies on therapeutic efficacy and toxicity." Proc. Natl. Acad. Sci. USA 95: 5357-5361 (1998) and Han, Z.T. et al. "12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced increase in depressed white blood cell counts in patients treated with cytotoxic cancer chemotherapeutic drugs." Proc. Natl. Acad. Sci. USA 95: 5362-5365 (1998).
- Beginning with our lot #F-151, we now guarantee purity of 99.5% or greater for this product as measured by HPLC at 254nm.
- Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
