P-1680 Phorbol 12-Myristate 13-Acetate, >99.5%

Synonyms : [Cocarcinogen A1] [12-O-Tetradecanoyl-phorbol 13-Acetate] [PMA] [TPA]

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  • 1 mg
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  • 5 mg
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  • M.W. 616.83
  • C36H56O8
  • [16561-29-8]
  • M.I. 12: 7487
  • M.I. 14: 7332

Warnings: Highly irritant to skin and mucous membranes. SPECIAL HAZARD: TUMOR PROMOTER. Gloves and mask should be worn when using this compound. Care must be taken to prevent contact through all routes of exposure.

Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO or ethanol. Disposal: A.

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  • LC Labs has been a primary worldwide supplier of PMA for laboratory research for more than 40 years
    • More than 330,000 vials of our PMA have been used by many thousands of labs since 1980
    • More than a dozen of the world's best-known biochemical reagent vendors resell our PMA under their own label
  • This is the most commonly used phorbol ester. It binds to and activates protein kinase C, causes an extremely wide range of effects in cells and tissues, and is a very potent mouse skin tumor promoter. Blumberg, P.M. "In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1." Crit. Rev. Toxicol. 8: 153-197 (1980) and Blumberg, P.M. "In vitro studies on the mode of action of the phorbol esters, potent tumor promoters, part 2." Crit. Rev. Toxicol. 8: 199-234 (1980).
  • Although PMA is quite toxic, it has shown anti-leukemic and anti-neutropenic activity in humans. Han, Z.T. et al. "Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia: preliminary studies on therapeutic efficacy and toxicity." Proc. Natl. Acad. Sci. USA 95: 5357-5361 (1998) and Han, Z.T. et al. "12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced increase in depressed white blood cell counts in patients treated with cytotoxic cancer chemotherapeutic drugs." Proc. Natl. Acad. Sci. USA 95: 5362-5365 (1998).
  • Beginning with our lot #F-151, we now guarantee purity of 99.5% or greater for this product as measured by HPLC at 254nm.
  • Please request Technical Note #14 for additional information.
  • Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
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