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P-1680 Phorbol 12-Myristate 13-Acetate, >99.5%
Related Terms : [PMA] [TPA] [Cocarcinogen A1] [12-O-Tetradecanoyl-phorbol 13-Acetate]
- Size
- US $
- €
- £
- ¥
- 1 mg
- 26
- 22
- 19
- 2,900
- In stock
- 5 mg
- 98
- 86
- 75
- 10,900
- In stock
- 10 mg
- 169
- 148
- 129
- 18,700
- In stock
- 25 mg
- 339
- 298
- 260
- 37,600
- In stock
- 100 mg
- 1,220
- 1,074
- 935
- 135,200
- In stock
Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
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- M.W. 616.83
- C36H56O8
- [16561-29-8]
- M.I. 12: 7487
- M.I. 14: 7332
Warnings: Highly irritant to skin and mucous membranes. SPECIAL HAZARD: TUMOR PROMOTER. Gloves and mask should be worn when using this compound. Care must be taken to prevent contact through all routes of exposure.
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO or ethanol. Disposal: A.
- LC Labs has been the primary worldwide supplier of PMA for laboratory research for more than 38 years
- More than 250,000 vials of our PMA have been used by many thousands of labs since 1980
- More than a dozen major biochemical reagent vendors sell our PMA under their own labels
- Thus, any PMA you may have used during the past few decades was mostly likely manufactured by LC Labs
- Our 1, 5, 10 and 25 mg sizes of PMA are now regularly supplied in crimp-top vials with teflon-lined septum seals for easy reconstitution and liquid handling. This new form of packaging replaces the flame-sealed snap-top vials that we used previously for those sizes.
- The 100 mg size of PMA will continue to be supplied in flame-sealed snap-top vials under a nitrogen atmosphere for long-term stability (many years).
- We continue to offer PMA in flame-sealed snap-top vials for all sizes. Please request "Flame-Sealed Vials" when placing your order.
- This is the most commonly used phorbol ester. It binds to and activates protein kinase C, causes an extremely wide range of effects in cells and tissues, and is a very potent mouse skin tumor promoter. Blumberg, P.M. "In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1." Crit. Rev. Toxicol. 8: 153-197 (1980) and Blumberg, P.M. "In vitro studies on the mode of action of the phorbol esters, potent tumor promoters, part 2." Crit. Rev. Toxicol. 8: 199-234 (1980).
- Although PMA is quite toxic, it has shown anti-leukemic and anti-neutropenic activity in humans. Han, Z.T. et al. "Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia: preliminary studies on therapeutic efficacy and toxicity." Proc. Natl. Acad. Sci. USA 95: 5357-5361 (1998) and Han, Z.T. et al. "12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced increase in depressed white blood cell counts in patients treated with cytotoxic cancer chemotherapeutic drugs." Proc. Natl. Acad. Sci. USA 95: 5362-5365 (1998).
- Beginning with our lot #F-151, we now guarantee purity of 99.5% or greater for this product as measured by HPLC at 254nm.
- Please request Technical Note #14 for additional information.
- Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
