Thursday 19 May 2022 - 04:28
Reminder: Genuine LC Laboratories® brand PMA, which we have been manufacturing in the U.S. for more
than 40 years, is available directly from us: Cat No. P-1680 Phorbol 12-Myristate 13-Acetate, >99.5%.
Our PMA is also available from our >50 U.S. and international distributors, and from more than a dozen
major biochemical reagent "resellers" (who sell our PMA under their own brand names and labels)
FREE SHIPPING TO THE U.S. AND 32 OTHER COUNTRIES! [Read more].
P-1680 Phorbol 12-Myristate 13-Acetate, >99.5%
Synonyms : [Cocarcinogen A1] [12-O-Tetradecanoyl-phorbol 13-Acetate] [PMA] [TPA]
- Size
- US $
- €
- £
- ¥
- 1 mg
- 34
- 32
- 27
- 4,400
- In stock
- 5 mg
- 103
- 97
- 83
- 13,300
- In stock
- 10 mg
- 194
- 184
- 156
- 25,100
- In stock
- 25 mg
- 388
- 368
- 312
- 50,200
- In stock
Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
- M.W. 616.83
- C36H56O8
- [16561-29-8]
- M.I. 12: 7487
- M.I. 14: 7332
Warnings: Highly irritant to skin and mucous membranes. SPECIAL HAZARD: TUMOR PROMOTER. Gloves and mask should be worn when using this compound. Care must be taken to prevent contact through all routes of exposure.
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO or ethanol. Disposal: A.
- LC Labs has been a primary worldwide supplier of PMA for laboratory research for more than 40 years
- More than 330,000 vials of our PMA have been used by many thousands of labs since 1980
- More than a dozen of the world's best-known biochemical reagent vendors resell our PMA under their own label
- This is the most commonly used phorbol ester. It binds to and activates protein kinase C, causes an extremely wide range of effects in cells and tissues, and is a very potent mouse skin tumor promoter. Blumberg, P.M. "In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: part 1." Crit. Rev. Toxicol. 8: 153-197 (1980) and Blumberg, P.M. "In vitro studies on the mode of action of the phorbol esters, potent tumor promoters, part 2." Crit. Rev. Toxicol. 8: 199-234 (1980).
- Although PMA is quite toxic, it has shown anti-leukemic and anti-neutropenic activity in humans. Han, Z.T. et al. "Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia: preliminary studies on therapeutic efficacy and toxicity." Proc. Natl. Acad. Sci. USA 95: 5357-5361 (1998) and Han, Z.T. et al. "12-O-Tetradecanoylphorbol-13-acetate (TPA)-induced increase in depressed white blood cell counts in patients treated with cytotoxic cancer chemotherapeutic drugs." Proc. Natl. Acad. Sci. USA 95: 5362-5365 (1998).
- Beginning with our lot #F-151, we now guarantee purity of 99.5% or greater for this product as measured by HPLC at 254nm.
- Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.