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P-4313 PD 98059, >99%
Related Terms : [2'-Amino-3'-methoxyflavone]
- Size
- US $
- €
- £
- ¥
- 10 mg
- 45
- 38
- 33
- 5,000
- In stock
- 25 mg
- 64
- 54
- 47
- 7,100
- In stock
- 50 mg
- 111
- 94
- 82
- 12,200
- In stock
- 100 mg
- 198
- 167
- 146
- 21,800
- In stock
- 200 mg
- 368
- 312
- 271
- 40,600
- In stock
- 250 mg
- 425
- 360
- 314
- 46,900
- In stock
- 300 mg
- 447
- 379
- 330
- 49,300
- In stock
- 500 mg
- 699
- 592
- 516
- 77,100
- In stock
- 1 g
- 1,335
- 1,132
- 986
- 147,200
- In stock
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- M.W. 267.28
- C16H13NO3
- [167869-21-8]
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 25 mg/mL; soluble in ethanol at 1 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A.
- More than 1,000 labs worldwide have purchased PD 98059 from LC Labs (either directly from us or from our many distributors, many of whom resell under their own labels).
- Potent, selective and cell-permeable inhibitor of MAP kinase kinase (also known as MAPK/ERK kinase or MEK kinase). Inhibits phosphorylation of MAP kinase by MAP kinase kinase. PD 98059 does not inhibit MAP kinase itself. IC50 values for PD 98059-induced effects are in the 1-20 µM range for many assays; it is somewhat weaker in inhibiting cell growth in monolayers or agar for some cell lines. Dudley, D.T., et al. "A synthetic inhibitor of the mitogen-activated protein kinase cascade." "Proc. Natl. Acad. Sci. USA 92: 7686-7689 (1995). Pang, L., et al. "Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor." J. Biol. Chem. 270: 13585-13588 (1995). Waters, S.B., et al. "Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex." J. Biol. Chem. 270: 20883-20886 (1995). Langlois, W.J., et al. "Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation." J. Biol. Chem. 270: 25320-25323 (1995). Alessi, D.R., et al. "PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo." J. Biol. Chem. 270: 27489-27494 (1995).
- Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
