P-4833 Phorbol 12,13-Dibutyrate, >99%

Synonyms : [PDBu]

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  • M.W. 504.61
  • C28H40O8
  • [37558-16-0]

Warnings: Highly irritant to skin and mucous membranes. SPECIAL HAZARD: TUMOR PROMOTER. Gloves and mask should be worn when using this compound. Care must be taken to prevent contact through all routes of exposure.

Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO or ethanol. Disposal: A.

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  • Widely used PKC activator; less potent than PMA, but also less hydrophobic, making it easier to wash out of cells in tissue culture
  • This was the ligand used, in radioactive form, in the discovery of the phorbol ester receptor. Driedger, P.E. and Blumberg, P.M. "Specific binding of phorbol ester tumor promoters." Proc. Natl. Acad. Sci. USA 77: 567-571 (1980).
  • Tritium-labeled PDBu, [3H]PDBu, is available from several suppliers of radiochemicals.
  • Please request Technical Note #14 for additional information.
  • Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
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