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R-1234 Roscovitine, Free Base, >99%
Related Terms : [CYC202] [Seliciclib] [6-Benzylamino-2[(R)-(1'-ethyl-2'-hydroxyethylamino)]-9-isopropylpurine]
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- 10 mg
- 58
- 49
- 42
- 6,400
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- 25 mg
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- 69
- 60
- 9,000
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- 50 mg
- 153
- 129
- 113
- 16,900
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- 100 mg
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- 181
- 158
- 23,600
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- 200 mg
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- 243
- 212
- 31,700
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- 300 mg
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- 338
- 294
- 44,000
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- 1 g
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- 685
- 102,200
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- M.W. 354.45
- C19H26N6O
- [186692-46-6]
- M.I. 14: 10240
Storage: Store at or below -20 ºC. Solubility: Prepare initial stock solutions in DMSO (soluble at 200 mg/mL) or ethanol (soluble at 200 mg/mL) for in vitro use; solubility in water is low. Appearance: White to off-white powder. Disposal: A.
- Roscovitine is a potent inhibitor of p34cdc2 (IC50 = 0.2 µM). Also inhibits p33cdk2 and p33cdk5. Havlicek, L., et al. "Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds." J. Med. Chem. 40: 408-412 (1997).
- NOTE: The word "Roscovitine" inherently means the R-isomer.
- Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
- This product is offered for R&D use in accordance with (i) 35 USC 271(e)+A13(1) in the U.S.; (ii) Section 69.1 of Japanese Patent Law in Japan; (iii) Section 11, No. 2 of the German Patent Act of 1981 in Germany; (iv) Section 60, Paragraph 5b of the U.K. Patents Act of 1977 in the U.K.; (v) Sections 55.2(1) and 55.2(6) and other common law exemptions of Canadian patent law; (vi) Section 68B of the Patents Act of 1953 in New Zealand together with the amendment of same by the Statutes Amendment Bill of 2002; (vii) such related legislation and/or case law as may be or become applicable in the aforementioned countries; and (viii) such similar laws and rules as may apply in various other countries.
- Not available in some countries; not available to some institutions; not available for some uses.
