Tuesday 27 September 2022 - 05:09
In Business 42 Years - Since 1980
Recently, we have been and are currently operating with: (1) staff shortages related to CV19 and other factors, (2) vacations, (3) a significant health burden for one senior staff member, and (4) dedication of substantial internal resources to a major public-service project. This situation is expected to continue through Sunday, September 11. During this time, we have been and expect to continue entering, processing and shipping orders normally for in-stock products. However, non-order-related communications and production of backordered products will be subject to some unusual delays. We apologize very much for this situation and appreciate your understanding.
FREE SHIPPING TO THE U.S. AND 32 OTHER COUNTRIES! [Read more].
S-1700 SB 202190, Free Base, >99%
Synonyms : [FHPI]
- Size
- US $
- €
- £
- ¥
- 25 mg
- 32
- 33
- 29
- 4,600
- In stock
- 50 mg
- 46
- 47
- 42
- 6,600
- In stock
- 100 mg
- 89
- 92
- 82
- 12,800
- In stock
- 200 mg
- 169
- 175
- 156
- 24,400
- In stock
Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
- M.W. 331.34
- C20H14FN3O
- [152121-30-7]
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A.
- SB202190, a pyridinyl imidazole, inhibits p38 kinase activity in vivo through competition with ATP. Young, P.R., et al. "Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site." J. Biol. Chem. 272: 12116-12121 (1997).
- Induces apoptosis through activation of cysteine protease (CPP32)-like caspases . Nemoto, S., et al. "Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase." J Biol Chem. 273: 16415-16420 (1998).
- Blocks both lipopolysaccharide (LPS)-induced gene expression and nitric oxide (NO)-induced stabilization of interleukin (IL)-8 mRNA in monocytes. Manthey, C.L., et al. "SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes." J. Leukoc. Biol. 64: 409-417 (1998). Ma, P., et al. "Nitric oxide post-transcriptionally up-regulates LPS-induced IL-8 expression through p38 MAPK activation." J. Leukoc. Biol. 76: 278-287 (2004).
- Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
