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S-3400 SB 203580, Free Base, >99%
Related Terms : [4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole]
- Size
- US $
- €
- £
- ¥
- 25 mg
- 55
- 46
- 40
- 6,100
- In stock
- 50 mg
- 72
- 61
- 53
- 7,900
- In stock
- 100 mg
- 129
- 109
- 95
- 14,200
- In stock
- 200 mg
- 228
- 193
- 168
- 25,100
- In stock
- 500 mg
- 527
- 446
- 389
- 58,100
- In stock
- 1 g
- 845
- 716
- 624
- 93,200
- In stock
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- M.W. 377.43
- C21H16FN3OS
- [152121-47-6]
- M.I. A
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 100 mg/mL; soluble in ethanol at 12.5 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM; buffers, serum, or other additives may increase or decrease the aqueous solubil.
- More than 1,000 labs worldwide have purchased SB 203580 from LC Labs (either directly from us or from our many distributors, many of whom resell under their own labels).
- Important, highly specific inhibitor of the kinase known variously as p38, p40, CSBP, or RK. This kinase is a homolog of MAP kinase. Gallagher, T.F., et al. "2,4,5-Triarylimidazole inhibitors of Il-1 biosynthesis." Bioorg. Med. Chem. Lett. 5: 1171-1176 (1995). Cuenda, A., et al. "SB203580 is a specific inhibitor of MAP kinase homologue which is stimulated by cellular stresses and interleukin-1." FEBS Lett.. 364: 229-233 (1995). Hazzalin, C.A., et al. "Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli." Oncogene 15: 2321-2331 (1997).
- Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
