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S-9344 Stauprimide, >99%
Related Terms : [N-Benzoyl-7-oxostaurosporine]
- Size
- US $
- €
- £
- ¥
- 1 mg
- 39
- 34
- 29
- 4,300
- In stock
- 5 mg
- 174
- 153
- 133
- 19,300
- In stock
- 10 mg
- 281
- 247
- 215
- 31,100
- In stock
- 25 mg
- 544
- 479
- 417
- 60,300
- In stock
- 100 mg
- 998
- 879
- 765
- 110,600
- In stock
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- M.W. 584.62
- C35H28N4O5
- [154589-96-5]
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 100 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A.
- Stauprimide increases the efficiency of directed differentiation of mouse and human embryonic stem cells (ESCs). Stauprimide binds to NME2 and inhibits its nuclear localization, thus leading to downregulation of c-Myc. Zhu, S., et al. "A small molecule primes embryonic stem cells for differentiation." Cell Stem Cell 4: 416-426 (2009).
- Stauprimide interacts with NME2, a c-Myc-activating transcription factor that is highly expressed in ESCs. Stauprimide treatment inhibits the nuclear localization of NME2 and downregulates c-Myc, enhances ESC exit from the pluripotent state and enables differentiation. Zaret, K. "Using Small Molecules to Great Effect in Stem Cell Differentiation." Cell Stem Cell 4: 373-374 (2009).
- Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
